Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determin...

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Detalles Bibliográficos
Autores principales: Irvine, David A., Zhang, Bin, Kinstrie, Ross, Tarafdar, Anuradha, Morrison, Heather, Campbell, Victoria L., Moka, Hothri A., Ho, Yinwei, Nixon, Colin, Manley, Paul W., Wheadon, Helen, Goodlad, John R., Holyoake, Tessa L., Bhatia, Ravi, Copland, Mhairi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860619/
https://www.ncbi.nlm.nih.gov/pubmed/27157927
http://dx.doi.org/10.1038/srep25476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860619/
https://www.ncbi.nlm.nih.gov/pubmed/27157927
http://dx.doi.org/10.1038/srep25476

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