Cargando…

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

Despite decades of intense global effort, no disease-modifying drugs for Alzheimer’s disease have emerged. Molecules targeting catalytic activities of γ-secretase or β-site APP-cleaving enzyme 1 (BACE1) have been beset by undesired side effects. We hypothesized that blocking the interaction between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Jin, Wang, Xiaoyin, Li, Xiaohang, Wang, Xin, Zhang, Chenlu, Li, Wei, Zhang, Yangming, Gu, Haifeng, Xie, Xin, Nan, Fajun, Zhao, Jian, Pei, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860824/ https://www.ncbi.nlm.nih.gov/pubmed/27462420 http://dx.doi.org/10.1038/celldisc.2015.21

Ejemplares similares

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
por: Ortega, Fernando, et al.
Publicado: (2013)

An Anti-Parkinson’s Disease Drug via Targeting Adenosine A(2A) Receptor Enhances Amyloid-β Generation and γ-Secretase Activity
por: Lu, Jing, et al.
Publicado: (2016)

Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease
por: He, Ping, et al.
Publicado: (2013)

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology
por: Liu, Xiaosong, et al.
Publicado: (2013)

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
por: Roberts, Hazel L., et al.
Publicado: (2017)

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation
por: Hu, Jin, et al.
Publicado: (2015)

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
por: Steiner, Harald, et al.
Publicado: (2018)

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
por: Pluta, Ryszard, et al.
Publicado: (2012)

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease
por: MacLeod, Ruth, et al.
Publicado: (2015)

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues
por: Devkota, Sujan, et al.
Publicado: (2021)

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease
por: Thathiah, Amantha, et al.
Publicado: (2013)

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production
por: Sano, Osamu, et al.
Publicado: (2016)

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
por: Xu, Ting-Hai, et al.
Publicado: (2016)

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
por: Schedin-Weiss, Sophia, et al.
Publicado: (2017)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors
por: Arslanova, Dilyara, et al.
Publicado: (2010)

Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
por: Laiterä, Tiina, et al.
Publicado: (2014)

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species
por: Wagner, Steven L., et al.
Publicado: (2014)

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio
por: Uemura, Kengo, et al.
Publicado: (2009)

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
por: Wang, Zhi-Hao, et al.
Publicado: (2018)

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
por: Sun, Xiaojuan, et al.
Publicado: (2015)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

β-Secretases, Alzheimer's Disease, and Down Syndrome
por: Webb, Robin L., et al.
Publicado: (2012)

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
por: Scholefield, Zoe, et al.
Publicado: (2003)

Visualization of Alzheimer’s Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
por: Wang, Xin, et al.
Publicado: (2018)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
por: Zhu, Bing, et al.
Publicado: (2017)

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
por: Ho, Michael, et al.
Publicado: (2010)

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase
por: Wang, Lie-Feng, et al.
Publicado: (2009)

High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90
por: Noorani, Arshad Ali, et al.
Publicado: (2021)

Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy
por: Liu, Zhonghua, et al.
Publicado: (2013)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

The Alzheimer's disease β-secretase enzyme, BACE1
por: Cole, Sarah L, et al.
Publicado: (2007)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
por: Raven, Frank, et al.
Publicado: (2017)

Turning the tide on Alzheimer’s disease: modulation of γ-secretase
por: Luo, Joanna E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_icjofb8l8vp1sffpapnpdsk971