AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation

AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However, AF9 function and related mechanisms in human neurodevelopment remain unknown. Here we show that AF9 is necessary and sufficient for human em...

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Detalles Bibliográficos
Autores principales: Qiao, Yunbo, Wang, Xiongjun, Wang, Ran, Li, Yuanyuan, Yu, Fang, Yang, Xianfa, Song, Lu, Xu, Guoliang, Chin, Y Eugene, Jing, Naihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860857/
https://www.ncbi.nlm.nih.gov/pubmed/27462416
http://dx.doi.org/10.1038/celldisc.2015.17

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