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Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration

The Hippo signaling pathway regulates tissue growth and organ size through controlling cell growth, proliferation and apoptosis. During these processes, the coactivator Yorkie partners with the transcription factor Scalloped to mediate Hippo pathway-regulated cellular functions. Here, we demonstrate...

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Autores principales: Wang, Chao, Yin, Meng-Xin, Wu, Wei, Dong, Liang, Wang, Shimin, Lu, Yi, Xu, Jinjin, Wu, Wenqing, Li, Sheng, Zhao, Yun, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860958/
https://www.ncbi.nlm.nih.gov/pubmed/27462453
http://dx.doi.org/10.1038/celldisc.2016.6
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author Wang, Chao
Yin, Meng-Xin
Wu, Wei
Dong, Liang
Wang, Shimin
Lu, Yi
Xu, Jinjin
Wu, Wenqing
Li, Sheng
Zhao, Yun
Zhang, Lei
author_facet Wang, Chao
Yin, Meng-Xin
Wu, Wei
Dong, Liang
Wang, Shimin
Lu, Yi
Xu, Jinjin
Wu, Wenqing
Li, Sheng
Zhao, Yun
Zhang, Lei
author_sort Wang, Chao
collection PubMed
description The Hippo signaling pathway regulates tissue growth and organ size through controlling cell growth, proliferation and apoptosis. During these processes, the coactivator Yorkie partners with the transcription factor Scalloped to mediate Hippo pathway-regulated cellular functions. Here, we demonstrate that Taiman facilitates the activity of Yorkie. First, Taiman overexpression upregulates Hippo pathway-responsive genes and induces tissue overgrowth. Second, the loss of tai downregulates the expression of Hippo pathway target genes and reduces organ size as well as tissue overgrowth caused by Yorkie overexpression. Furthermore, we provide evidence that Taiman binds to Yorkie and facilitates the activity of Yorkie-Scalloped to activate the transcription of several Hippo pathway target genes. Moreover, we found that the C-terminus of Taiman is indispensable for the function of Taiman in Hippo signaling. Finally, we demonstrate that Taiman is also required in intestinal stem cell proliferation. Our findings suggest Taiman is an essential coactivator of Yorkie.
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spelling pubmed-48609582016-07-26 Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration Wang, Chao Yin, Meng-Xin Wu, Wei Dong, Liang Wang, Shimin Lu, Yi Xu, Jinjin Wu, Wenqing Li, Sheng Zhao, Yun Zhang, Lei Cell Discov Article The Hippo signaling pathway regulates tissue growth and organ size through controlling cell growth, proliferation and apoptosis. During these processes, the coactivator Yorkie partners with the transcription factor Scalloped to mediate Hippo pathway-regulated cellular functions. Here, we demonstrate that Taiman facilitates the activity of Yorkie. First, Taiman overexpression upregulates Hippo pathway-responsive genes and induces tissue overgrowth. Second, the loss of tai downregulates the expression of Hippo pathway target genes and reduces organ size as well as tissue overgrowth caused by Yorkie overexpression. Furthermore, we provide evidence that Taiman binds to Yorkie and facilitates the activity of Yorkie-Scalloped to activate the transcription of several Hippo pathway target genes. Moreover, we found that the C-terminus of Taiman is indispensable for the function of Taiman in Hippo signaling. Finally, we demonstrate that Taiman is also required in intestinal stem cell proliferation. Our findings suggest Taiman is an essential coactivator of Yorkie. Nature Publishing Group 2016-03-22 /pmc/articles/PMC4860958/ /pubmed/27462453 http://dx.doi.org/10.1038/celldisc.2016.6 Text en Copyright © 2016 SIBS, CAS http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Chao
Yin, Meng-Xin
Wu, Wei
Dong, Liang
Wang, Shimin
Lu, Yi
Xu, Jinjin
Wu, Wenqing
Li, Sheng
Zhao, Yun
Zhang, Lei
Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title_full Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title_fullStr Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title_full_unstemmed Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title_short Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
title_sort taiman acts as a coactivator of yorkie in the hippo pathway to promote tissue growth and intestinal regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860958/
https://www.ncbi.nlm.nih.gov/pubmed/27462453
http://dx.doi.org/10.1038/celldisc.2016.6
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