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Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent degradation by the 26S proteasome. Notably, emerging evidence suggested that Cdh1 could also f...

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Detalles Bibliográficos
Autores principales:	Liu, Jia, Wan, Lixin, Liu, Jing, Yuan, Zhu, Zhang, Jinfang, Guo, Jianfeng, Malumbres, Marcos, Liu, Jiankang, Zou, Weiguo, Wei, Wenyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860961/ https://www.ncbi.nlm.nih.gov/pubmed/27462441 http://dx.doi.org/10.1038/celldisc.2015.44

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