Lead identification for the K-Ras protein: virtual screening and combinatorial fragment-based approaches

OBJECTIVE: Kirsten rat sarcoma (K-Ras) protein is a member of Ras family belonging to the small guanosine triphosphatases superfamily. The members of this family share a conserved structure and biochemical properties, acting as binary molecular switches. The guanosine triphosphate-bound active K-Ras...

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Detalles Bibliográficos
Autores principales: Pathan, Akbar Ali Khan, Panthi, Bhavana, Khan, Zahid, Koppula, Purushotham Reddy, Alanazi, Mohammed Saud, Sachchidanand, Parine, Narasimha Reddy, Chourasia, Mukesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861002/
https://www.ncbi.nlm.nih.gov/pubmed/27217775
http://dx.doi.org/10.2147/OTT.S99671

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