The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands

In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to (3)H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes. Binding affinities were measured by displacing...

Descripción completa

Detalles Bibliográficos
Autores principales: Kržan, Mojca, Vianello, Robert, Maršavelski, Aleksandra, Repič, Matej, Zakšek, Maja, Kotnik, Kristina, Fijan, Estera, Mavri, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861267/
https://www.ncbi.nlm.nih.gov/pubmed/27159606
http://dx.doi.org/10.1371/journal.pone.0154002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861267/
https://www.ncbi.nlm.nih.gov/pubmed/27159606
http://dx.doi.org/10.1371/journal.pone.0154002

Ejemplares similares