Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer

LESSONS LEARNED: Despite evidence for a role for prolactin signaling in breast and prostate tumorigenesis, a prolactin receptor-binding monoclonal antibody has not produced clinical efficacy. Increased serum prolactin levels may be a biomarker for prolactin receptor inhibition. Results from the phar...

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Detalles Bibliográficos
Autores principales: Agarwal, Neeraj, Machiels, Jean-Pascal, Suárez, Cristina, Lewis, Nancy, Higgins, Michaela, Wisinski, Kari, Awada, Ahmad, Maur, Michela, Stein, Mark, Hwang, Andy, Mosher, Rebecca, Wasserman, Ernesto, Wu, Gang, Zhang, Hefei, Zieba, Renata, Elmeliegy, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2016
Materias:
Clinical Trial Results
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861370/
https://www.ncbi.nlm.nih.gov/pubmed/27091421
http://dx.doi.org/10.1634/theoncologist.2015-0502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861370/
https://www.ncbi.nlm.nih.gov/pubmed/27091421
http://dx.doi.org/10.1634/theoncologist.2015-0502

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