Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that contains a quinazolinone nucleus, we synthesized four series of 3-vinyl-quinoxalin-2(1H)-one derivatives, a total of 27 compounds. We furthe...

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Detalles Bibliográficos
Autores principales: Liu, Zhiguo, Yu, Shufang, Chen, Di, Shen, Guoliang, Wang, Yu, Hou, Leping, Lin, Dan, Zhang, Jinsan, Ye, Faqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861610/
https://www.ncbi.nlm.nih.gov/pubmed/27217720
http://dx.doi.org/10.2147/DDDT.S88587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861610/
https://www.ncbi.nlm.nih.gov/pubmed/27217720
http://dx.doi.org/10.2147/DDDT.S88587

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