Cargando…

Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo

Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer genomics(1,2). There are nine hot spots of DSBs located in human rDNA units(3–6). Here we describe that the profiles of these hot spots coincide with the profiles of γ-H2AX or H2AX, stro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tchurikov, Nickolai A., Yudkin, Dmitry V., Gorbacheva, Maria A., Kulemzina, Anastasia I., Grischenko, Irina V., Fedoseeva, Daria M., Sosin, Dmitri V., Kravatsky, Yuri V., Kretova, Olga V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861929/ https://www.ncbi.nlm.nih.gov/pubmed/27160357 http://dx.doi.org/10.1038/srep25866

Ejemplares similares

Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation
por: Tchurikov, Nickolai A., et al.
Publicado: (2015)

Genome-wide mapping of hot spots of DNA double-strand breaks in human cells as a tool for epigenetic studies and cancer genomics
por: Tchurikov, N.A., et al.
Publicado: (2015)

Mapping of genomic double-strand breaks by ligation of biotinylated oligonucleotides to forum domains: Analysis of the data obtained for human rDNA units
por: Tchurikov, N.A., et al.
Publicado: (2014)

DNA Double-Strand Breaks Coupled with PARP1 and HNRNPA2B1 Binding Sites Flank Coordinately Expressed Domains in Human Chromosomes
por: Tchurikov, Nickolai A., et al.
Publicado: (2013)

rDNA Clusters Make Contact with Genes that Are Involved in Differentiation and Cancer and Change Contacts after Heat Shock Treatment
por: Tchurikov, Nickolai A., et al.
Publicado: (2019)

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation
por: Tchurikov, Nickolai A., et al.
Publicado: (2020)

The Role of rDNA Clusters in Global Epigenetic Gene Regulation
por: Tchurikov, Nickolai A., et al.
Publicado: (2021)

A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology
por: Kravatsky, Yuri, et al.
Publicado: (2017)

Fragments of rDNA Genes Scattered over the Human Genome Are Targets of Small RNAs
por: Tchurikov, Nickolai A., et al.
Publicado: (2022)

Induction of the Erythroid Differentiation of K562 Cells Is Coupled with Changes in the Inter-Chromosomal Contacts of rDNA Clusters
por: Tchurikov, Nickolai A., et al.
Publicado: (2023)

Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs
por: Tchurikov, Nickolai A., et al.
Publicado: (2021)

Genome-wide profiling of forum domains in Drosophila melanogaster
por: Tchurikov, Nickolai A., et al.
Publicado: (2011)

Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide
por: Kretova, Olga V., et al.
Publicado: (2017)

Genes Possessing the Most Frequent DNA DSBs Are Highly Associated with Development and Cancers, and Essentially Overlap with the rDNA-Contacting Genes
por: Tchurikov, Nickolai A., et al.
Publicado: (2022)

Evidence for RNA synthesis in the intergenic region between enhancer and promoter and its inhibition by insulators in Drosophila melanogaster
por: Tchurikov, Nickolai A., et al.
Publicado: (2009)

Suffix-specific RNAi Leads to Silencing of F Element in Drosophila melanogaster
por: Tchurikov, Nickolai A., et al.
Publicado: (2007)

Both piRNA and siRNA Pathways Are Silencing Transcripts of the Suffix Element in the Drosophila melanogaster Germline and Somatic Cells
por: Tchurikov, Nickolai A., et al.
Publicado: (2011)

Plasmonic hot spots reveal local conformational transitions induced by DNA double-strand breaks
por: Seweryn, Sara, et al.
Publicado: (2022)

Genome-Wide Study of Colocalization between Genomic Stretches: A Method and Applications to the Regulation of Gene Expression
por: Kravatsky, Yuri V., et al.
Publicado: (2022)

The Influence of DNA Configuration on the Direct Strand Break Yield
por: Bernal, M. A., et al.
Publicado: (2015)

Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription
por: Xie, Qiu, et al.
Publicado: (2017)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks
por: Loshchenova, Polina S, et al.
Publicado: (2020)

H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues
por: Firsanov, Denis V., et al.
Publicado: (2011)

Temperature-dependent regulation of rDNA condensation in Saccharomyces cerevisiae
por: Shen, Donglai, et al.
Publicado: (2017)

Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae
por: Shen, Donglai, et al.
Publicado: (2020)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

Radiation-induced DNA double-strand break rejoining in human tumour cells.
por: Núñez, M. I., et al.
Publicado: (1995)

The helicase DinG responds to stress due to DNA double strand breaks
por: Frye, Stephan A., et al.
Publicado: (2017)

The ubiquitin landscape at DNA double-strand breaks
por: Messick, Troy E., et al.
Publicado: (2009)

Genome-Wide Mapping of DNA Strand Breaks
por: Leduc, Frédéric, et al.
Publicado: (2011)

Nucleolar responses to DNA double-strand breaks
por: Larsen, Dorthe Helena, et al.
Publicado: (2016)

Repair of DNA Double-Strand Breaks in Heterochromatin
por: Watts, Felicity Z.
Publicado: (2016)

Physiological Roles of DNA Double-Strand Breaks
por: Khan, Farhaan A., et al.
Publicado: (2017)

Boon and Bane of DNA Double-Strand Breaks
por: Schubert, Ingo
Publicado: (2021)

The Fate of Oxidative Strand Breaks in Mitochondrial DNA
por: Trombly, Genevieve, et al.
Publicado: (2023)

Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity
por: Oeck, S., et al.
Publicado: (2017)

Genome-wide study of correlations between genomic features and their relationship with the regulation of gene expression
por: Kravatsky, Yuri V., et al.
Publicado: (2015)

Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks
por: Girst, S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6bp0sc7cl3oqlviiehq34brsca