Osthole inhibits histamine-dependent itch via modulating TRPV1 activity

Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imagi...

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Detalles Bibliográficos
Autores principales: Yang, Niu-Niu, Shi, Hao, Yu, Guang, Wang, Chang-Ming, Zhu, Chan, Yang, Yan, Yuan, Xiao-Lin, Tang, Min, Wang, Zhong-li, Gegen, Tana, He, Qian, Tang, Kehua, Lan, Lei, Wu, Guan-Yi, Tang, Zong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861971/
https://www.ncbi.nlm.nih.gov/pubmed/27160770
http://dx.doi.org/10.1038/srep25657

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