Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2

Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50%. Molecular targeted therapies are not in routine use and novel therapeutic targets are required. Our previous microarray data indicated sphingosine 1-phosphate (S1P) metabolism and signalling was dereg...

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Detalles Bibliográficos
Autores principales: Patmanathan, Sathya Narayanan, Johnson, Steven P., Lai, Sook Ling, Panja Bernam, Suthashini, Lopes, Victor, Wei, Wenbin, Ibrahim, Maha Hafez, Torta, Federico, Narayanaswamy, Pradeep, Wenk, Markus R., Herr, Deron R., Murray, Paul G., Yap, Lee Fah, Paterson, Ian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861980/
https://www.ncbi.nlm.nih.gov/pubmed/27160553
http://dx.doi.org/10.1038/srep25650

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