Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off‐the‐shelf after lo...

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Autores principales: Celiz, Adam D., Smith, James G. W., Patel, Asha K., Hook, Andrew L., Rajamohan, Divya, George, Vinoj T., Flatt, Luke, Patel, Minal J., Epa, Vidana C., Singh, Taranjit, Langer, Robert, Anderson, Daniel G., Allen, Nicholas D., Hay, David C., Winkler, David A., Barrett, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris, Alexander, Morgan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862031/
https://www.ncbi.nlm.nih.gov/pubmed/26033422
http://dx.doi.org/10.1002/adma.201501351
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author Celiz, Adam D.
Smith, James G. W.
Patel, Asha K.
Hook, Andrew L.
Rajamohan, Divya
George, Vinoj T.
Flatt, Luke
Patel, Minal J.
Epa, Vidana C.
Singh, Taranjit
Langer, Robert
Anderson, Daniel G.
Allen, Nicholas D.
Hay, David C.
Winkler, David A.
Barrett, David A.
Davies, Martyn C.
Young, Lorraine E.
Denning, Chris
Alexander, Morgan R.
author_facet Celiz, Adam D.
Smith, James G. W.
Patel, Asha K.
Hook, Andrew L.
Rajamohan, Divya
George, Vinoj T.
Flatt, Luke
Patel, Minal J.
Epa, Vidana C.
Singh, Taranjit
Langer, Robert
Anderson, Daniel G.
Allen, Nicholas D.
Hay, David C.
Winkler, David A.
Barrett, David A.
Davies, Martyn C.
Young, Lorraine E.
Denning, Chris
Alexander, Morgan R.
author_sort Celiz, Adam D.
collection PubMed
description A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off‐the‐shelf after long‐term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC‐derived cells to be realized. [Image: see text]
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spelling pubmed-48620312016-06-22 Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation Celiz, Adam D. Smith, James G. W. Patel, Asha K. Hook, Andrew L. Rajamohan, Divya George, Vinoj T. Flatt, Luke Patel, Minal J. Epa, Vidana C. Singh, Taranjit Langer, Robert Anderson, Daniel G. Allen, Nicholas D. Hay, David C. Winkler, David A. Barrett, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. Adv Mater Communications A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off‐the‐shelf after long‐term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC‐derived cells to be realized. [Image: see text] John Wiley and Sons Inc. 2015-07-15 2015-06-01 /pmc/articles/PMC4862031/ /pubmed/26033422 http://dx.doi.org/10.1002/adma.201501351 Text en © 2015 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Celiz, Adam D.
Smith, James G. W.
Patel, Asha K.
Hook, Andrew L.
Rajamohan, Divya
George, Vinoj T.
Flatt, Luke
Patel, Minal J.
Epa, Vidana C.
Singh, Taranjit
Langer, Robert
Anderson, Daniel G.
Allen, Nicholas D.
Hay, David C.
Winkler, David A.
Barrett, David A.
Davies, Martyn C.
Young, Lorraine E.
Denning, Chris
Alexander, Morgan R.
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title_full Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title_fullStr Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title_full_unstemmed Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title_short Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
title_sort discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862031/
https://www.ncbi.nlm.nih.gov/pubmed/26033422
http://dx.doi.org/10.1002/adma.201501351
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