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Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)

BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The pa...

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Autores principales: Su, Yong, Mo, Chuan-wei, Cheng, Wan-qin, Wang, Lei, Xu, Qian, Wu, Zu-chun, Wu, Zhe-li, Liu, Li-zhi, Chen, Xin-lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862168/
https://www.ncbi.nlm.nih.gov/pubmed/27164979
http://dx.doi.org/10.1186/s12955-016-0480-0
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author Su, Yong
Mo, Chuan-wei
Cheng, Wan-qin
Wang, Lei
Xu, Qian
Wu, Zu-chun
Wu, Zhe-li
Liu, Li-zhi
Chen, Xin-lin
author_facet Su, Yong
Mo, Chuan-wei
Cheng, Wan-qin
Wang, Lei
Xu, Qian
Wu, Zu-chun
Wu, Zhe-li
Liu, Li-zhi
Chen, Xin-lin
author_sort Su, Yong
collection PubMed
description BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. RESULTS: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from −0.82 to −0.22. CONCLUSIONS: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients.
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spelling pubmed-48621682016-05-11 Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) Su, Yong Mo, Chuan-wei Cheng, Wan-qin Wang, Lei Xu, Qian Wu, Zu-chun Wu, Zhe-li Liu, Li-zhi Chen, Xin-lin Health Qual Life Outcomes Research BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. RESULTS: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from −0.82 to −0.22. CONCLUSIONS: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients. BioMed Central 2016-05-10 /pmc/articles/PMC4862168/ /pubmed/27164979 http://dx.doi.org/10.1186/s12955-016-0480-0 Text en © Su et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Su, Yong
Mo, Chuan-wei
Cheng, Wan-qin
Wang, Lei
Xu, Qian
Wu, Zu-chun
Wu, Zhe-li
Liu, Li-zhi
Chen, Xin-lin
Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title_full Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title_fullStr Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title_full_unstemmed Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title_short Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
title_sort development and validation of quality of life scale of nasopharyngeal carcinoma patients: the qol-npc (version 2)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862168/
https://www.ncbi.nlm.nih.gov/pubmed/27164979
http://dx.doi.org/10.1186/s12955-016-0480-0
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