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Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2)
BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The pa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862168/ https://www.ncbi.nlm.nih.gov/pubmed/27164979 http://dx.doi.org/10.1186/s12955-016-0480-0 |
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author | Su, Yong Mo, Chuan-wei Cheng, Wan-qin Wang, Lei Xu, Qian Wu, Zu-chun Wu, Zhe-li Liu, Li-zhi Chen, Xin-lin |
author_facet | Su, Yong Mo, Chuan-wei Cheng, Wan-qin Wang, Lei Xu, Qian Wu, Zu-chun Wu, Zhe-li Liu, Li-zhi Chen, Xin-lin |
author_sort | Su, Yong |
collection | PubMed |
description | BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. RESULTS: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from −0.82 to −0.22. CONCLUSIONS: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients. |
format | Online Article Text |
id | pubmed-4862168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48621682016-05-11 Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) Su, Yong Mo, Chuan-wei Cheng, Wan-qin Wang, Lei Xu, Qian Wu, Zu-chun Wu, Zhe-li Liu, Li-zhi Chen, Xin-lin Health Qual Life Outcomes Research BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. RESULTS: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from −0.82 to −0.22. CONCLUSIONS: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients. BioMed Central 2016-05-10 /pmc/articles/PMC4862168/ /pubmed/27164979 http://dx.doi.org/10.1186/s12955-016-0480-0 Text en © Su et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Su, Yong Mo, Chuan-wei Cheng, Wan-qin Wang, Lei Xu, Qian Wu, Zu-chun Wu, Zhe-li Liu, Li-zhi Chen, Xin-lin Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title | Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title_full | Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title_fullStr | Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title_full_unstemmed | Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title_short | Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2) |
title_sort | development and validation of quality of life scale of nasopharyngeal carcinoma patients: the qol-npc (version 2) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862168/ https://www.ncbi.nlm.nih.gov/pubmed/27164979 http://dx.doi.org/10.1186/s12955-016-0480-0 |
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