Cargando…

ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force

The ATP-sensitive K(+)-channels (KATP) are distributed in the tissues coupling metabolism with K(+) ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1), and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR variants that confer distinct physiological p...

Descripción completa

Detalles Bibliográficos
Autores principales: Tricarico, Domenico, Selvaggi, Maria, Passantino, Giuseppe, De Palo, Pasquale, Dario, Cataldo, Centoducati, Pasquale, Tateo, Alessandra, Curci, Angela, Maqoud, Fatima, Mele, Antonietta, Camerino, Giulia M., Liantonio, Antonella, Imbrici, Paola, Zizzo, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862255/
https://www.ncbi.nlm.nih.gov/pubmed/27242541
http://dx.doi.org/10.3389/fphys.2016.00167
_version_ 1782431336574746624
author Tricarico, Domenico
Selvaggi, Maria
Passantino, Giuseppe
De Palo, Pasquale
Dario, Cataldo
Centoducati, Pasquale
Tateo, Alessandra
Curci, Angela
Maqoud, Fatima
Mele, Antonietta
Camerino, Giulia M.
Liantonio, Antonella
Imbrici, Paola
Zizzo, Nicola
author_facet Tricarico, Domenico
Selvaggi, Maria
Passantino, Giuseppe
De Palo, Pasquale
Dario, Cataldo
Centoducati, Pasquale
Tateo, Alessandra
Curci, Angela
Maqoud, Fatima
Mele, Antonietta
Camerino, Giulia M.
Liantonio, Antonella
Imbrici, Paola
Zizzo, Nicola
author_sort Tricarico, Domenico
collection PubMed
description The ATP-sensitive K(+)-channels (KATP) are distributed in the tissues coupling metabolism with K(+) ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1), and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR variants that confer distinct physiological properties on the channel. An high expression/activity of the sarco-KATP channel is observed in various rat fast-twitch muscles, characterized by elevated muscle strength, while a low expression/activity is observed in the slow-twitch muscles characterized by reduced strength and frailty. Down-regulation of the KATP subunits of fast-twitch fibers is found in conditions characterized by weakness and frailty. KCNJ11 gene knockout mice have reduced glycogen, lean phenotype, lower body fat, and weakness. KATP channel is also a sensor of muscle atrophy. The KCNJ11 gene is located on BTA15, close to a QTL for meat tenderness, it has also a role in glycogen storage, a key mechanism of the postmortem transformation of muscle into meat. The role of KCNJ11 gene in muscle function may underlie an effect of KCNJ11 genotypes on meat tenderness, as recently reported. The fiber phenotype and genotype are important in livestock production science. Quantitative traits including meat production and quality are influenced both by environment and genes. Molecular markers can play an important role in the genetic improvement of animals through breeding strategies. Many factors influence the muscle Warner-Bratzler shear force including breed, age, feeding, the biochemical, and functional parameters. The role of KCNJ11gene and related genes on muscle tenderness will be discussed in the present review.
format Online
Article
Text
id pubmed-4862255
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-48622552016-05-30 ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force Tricarico, Domenico Selvaggi, Maria Passantino, Giuseppe De Palo, Pasquale Dario, Cataldo Centoducati, Pasquale Tateo, Alessandra Curci, Angela Maqoud, Fatima Mele, Antonietta Camerino, Giulia M. Liantonio, Antonella Imbrici, Paola Zizzo, Nicola Front Physiol Physiology The ATP-sensitive K(+)-channels (KATP) are distributed in the tissues coupling metabolism with K(+) ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1), and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR variants that confer distinct physiological properties on the channel. An high expression/activity of the sarco-KATP channel is observed in various rat fast-twitch muscles, characterized by elevated muscle strength, while a low expression/activity is observed in the slow-twitch muscles characterized by reduced strength and frailty. Down-regulation of the KATP subunits of fast-twitch fibers is found in conditions characterized by weakness and frailty. KCNJ11 gene knockout mice have reduced glycogen, lean phenotype, lower body fat, and weakness. KATP channel is also a sensor of muscle atrophy. The KCNJ11 gene is located on BTA15, close to a QTL for meat tenderness, it has also a role in glycogen storage, a key mechanism of the postmortem transformation of muscle into meat. The role of KCNJ11 gene in muscle function may underlie an effect of KCNJ11 genotypes on meat tenderness, as recently reported. The fiber phenotype and genotype are important in livestock production science. Quantitative traits including meat production and quality are influenced both by environment and genes. Molecular markers can play an important role in the genetic improvement of animals through breeding strategies. Many factors influence the muscle Warner-Bratzler shear force including breed, age, feeding, the biochemical, and functional parameters. The role of KCNJ11gene and related genes on muscle tenderness will be discussed in the present review. Frontiers Media S.A. 2016-05-10 /pmc/articles/PMC4862255/ /pubmed/27242541 http://dx.doi.org/10.3389/fphys.2016.00167 Text en Copyright © 2016 Tricarico, Selvaggi, Passantino, De Palo, Dario, Centoducati, Tateo, Curci, Maqoud, Mele, Camerino, Liantonio, Imbrici and Zizzo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tricarico, Domenico
Selvaggi, Maria
Passantino, Giuseppe
De Palo, Pasquale
Dario, Cataldo
Centoducati, Pasquale
Tateo, Alessandra
Curci, Angela
Maqoud, Fatima
Mele, Antonietta
Camerino, Giulia M.
Liantonio, Antonella
Imbrici, Paola
Zizzo, Nicola
ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title_full ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title_fullStr ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title_full_unstemmed ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title_short ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
title_sort atp sensitive potassium channels in the skeletal muscle function: involvement of the kcnj11(kir6.2) gene in the determination of mechanical warner bratzer shear force
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862255/
https://www.ncbi.nlm.nih.gov/pubmed/27242541
http://dx.doi.org/10.3389/fphys.2016.00167
work_keys_str_mv AT tricaricodomenico atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT selvaggimaria atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT passantinogiuseppe atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT depalopasquale atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT dariocataldo atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT centoducatipasquale atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT tateoalessandra atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT curciangela atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT maqoudfatima atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT meleantonietta atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT camerinogiuliam atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT liantonioantonella atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT imbricipaola atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce
AT zizzonicola atpsensitivepotassiumchannelsintheskeletalmusclefunctioninvolvementofthekcnj11kir62geneinthedeterminationofmechanicalwarnerbratzershearforce