Tipping the spindle into the right position

The position of the mitotic spindle determines the cleavage plane in animal cells, but what controls spindle positioning? Kern et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510117) demonstrate that the microtubule plus end–associated SKAP/Astrin complex participates in this process, p...

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Detalles Bibliográficos
Autores principales: Akhmanova, Anna, van den Heuvel, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862335/
https://www.ncbi.nlm.nih.gov/pubmed/27138251
http://dx.doi.org/10.1083/jcb.201604075
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author Akhmanova, Anna
van den Heuvel, Sander
author_facet Akhmanova, Anna
van den Heuvel, Sander
author_sort Akhmanova, Anna
collection PubMed
description The position of the mitotic spindle determines the cleavage plane in animal cells, but what controls spindle positioning? Kern et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510117) demonstrate that the microtubule plus end–associated SKAP/Astrin complex participates in this process, possibly by affecting dynein-dependent pulling forces exerted on the tips of astral microtubules.
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spelling pubmed-48623352016-11-09 Tipping the spindle into the right position Akhmanova, Anna van den Heuvel, Sander J Cell Biol Commentary The position of the mitotic spindle determines the cleavage plane in animal cells, but what controls spindle positioning? Kern et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510117) demonstrate that the microtubule plus end–associated SKAP/Astrin complex participates in this process, possibly by affecting dynein-dependent pulling forces exerted on the tips of astral microtubules. The Rockefeller University Press 2016-05-09 /pmc/articles/PMC4862335/ /pubmed/27138251 http://dx.doi.org/10.1083/jcb.201604075 Text en © 2016 Akhmanova and van den Heuvel This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Akhmanova, Anna
van den Heuvel, Sander
Tipping the spindle into the right position
title Tipping the spindle into the right position
title_full Tipping the spindle into the right position
title_fullStr Tipping the spindle into the right position
title_full_unstemmed Tipping the spindle into the right position
title_short Tipping the spindle into the right position
title_sort tipping the spindle into the right position
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862335/
https://www.ncbi.nlm.nih.gov/pubmed/27138251
http://dx.doi.org/10.1083/jcb.201604075
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