Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor pano...

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Autores principales: Grasso, Catherine S., Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E., Liu, Lining, Debily, Marie-Anne, Quist, Michael J., Davis, Lara E., Huang, Elaine C., Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B., Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Lin, Qi, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E., Dret, Ludivine Le, Meltzer, Paul S., Mao, Hua, Quezado, Martha, van Vuurden, Dannis G., Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N., Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M., Raabe, Eric, Hulleman, Esther, Spellman, Paul T., Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862411/
https://www.ncbi.nlm.nih.gov/pubmed/25939062
http://dx.doi.org/10.1038/nm.3855
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author Grasso, Catherine S.
Tang, Yujie
Truffaux, Nathalene
Berlow, Noah E.
Liu, Lining
Debily, Marie-Anne
Quist, Michael J.
Davis, Lara E.
Huang, Elaine C.
Woo, Pamelyn J
Ponnuswami, Anitha
Chen, Spenser
Johung, Tessa B.
Sun, Wenchao
Kogiso, Mari
Du, Yuchen
Lin, Qi
Huang, Yulun
Hütt-Cabezas, Marianne
Warren, Katherine E.
Dret, Ludivine Le
Meltzer, Paul S.
Mao, Hua
Quezado, Martha
van Vuurden, Dannis G.
Abraham, Jinu
Fouladi, Maryam
Svalina, Matthew N.
Wang, Nicholas
Hawkins, Cynthia
Nazarian, Javad
Alonso, Marta M.
Raabe, Eric
Hulleman, Esther
Spellman, Paul T.
Li, Xiao-Nan
Keller, Charles
Pal, Ranadip
Grill, Jacques
Monje, Michelle
author_facet Grasso, Catherine S.
Tang, Yujie
Truffaux, Nathalene
Berlow, Noah E.
Liu, Lining
Debily, Marie-Anne
Quist, Michael J.
Davis, Lara E.
Huang, Elaine C.
Woo, Pamelyn J
Ponnuswami, Anitha
Chen, Spenser
Johung, Tessa B.
Sun, Wenchao
Kogiso, Mari
Du, Yuchen
Lin, Qi
Huang, Yulun
Hütt-Cabezas, Marianne
Warren, Katherine E.
Dret, Ludivine Le
Meltzer, Paul S.
Mao, Hua
Quezado, Martha
van Vuurden, Dannis G.
Abraham, Jinu
Fouladi, Maryam
Svalina, Matthew N.
Wang, Nicholas
Hawkins, Cynthia
Nazarian, Javad
Alonso, Marta M.
Raabe, Eric
Hulleman, Esther
Spellman, Paul T.
Li, Xiao-Nan
Keller, Charles
Pal, Ranadip
Grill, Jacques
Monje, Michelle
author_sort Grasso, Catherine S.
collection PubMed
description Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated efficacy in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat with histone demethylase inhibitor GSKJ4 revealed synergy. Together, these data suggest a promising therapeutic strategy for DIPG.
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spelling pubmed-48624112016-05-10 Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium Grasso, Catherine S. Tang, Yujie Truffaux, Nathalene Berlow, Noah E. Liu, Lining Debily, Marie-Anne Quist, Michael J. Davis, Lara E. Huang, Elaine C. Woo, Pamelyn J Ponnuswami, Anitha Chen, Spenser Johung, Tessa B. Sun, Wenchao Kogiso, Mari Du, Yuchen Lin, Qi Huang, Yulun Hütt-Cabezas, Marianne Warren, Katherine E. Dret, Ludivine Le Meltzer, Paul S. Mao, Hua Quezado, Martha van Vuurden, Dannis G. Abraham, Jinu Fouladi, Maryam Svalina, Matthew N. Wang, Nicholas Hawkins, Cynthia Nazarian, Javad Alonso, Marta M. Raabe, Eric Hulleman, Esther Spellman, Paul T. Li, Xiao-Nan Keller, Charles Pal, Ranadip Grill, Jacques Monje, Michelle Nat Med Article Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated efficacy in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat with histone demethylase inhibitor GSKJ4 revealed synergy. Together, these data suggest a promising therapeutic strategy for DIPG. 2015-05-04 2015-06 /pmc/articles/PMC4862411/ /pubmed/25939062 http://dx.doi.org/10.1038/nm.3855 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Grasso, Catherine S.
Tang, Yujie
Truffaux, Nathalene
Berlow, Noah E.
Liu, Lining
Debily, Marie-Anne
Quist, Michael J.
Davis, Lara E.
Huang, Elaine C.
Woo, Pamelyn J
Ponnuswami, Anitha
Chen, Spenser
Johung, Tessa B.
Sun, Wenchao
Kogiso, Mari
Du, Yuchen
Lin, Qi
Huang, Yulun
Hütt-Cabezas, Marianne
Warren, Katherine E.
Dret, Ludivine Le
Meltzer, Paul S.
Mao, Hua
Quezado, Martha
van Vuurden, Dannis G.
Abraham, Jinu
Fouladi, Maryam
Svalina, Matthew N.
Wang, Nicholas
Hawkins, Cynthia
Nazarian, Javad
Alonso, Marta M.
Raabe, Eric
Hulleman, Esther
Spellman, Paul T.
Li, Xiao-Nan
Keller, Charles
Pal, Ranadip
Grill, Jacques
Monje, Michelle
Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title_full Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title_fullStr Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title_full_unstemmed Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title_short Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium
title_sort functionally-defined therapeutic targets in diffuse intrinsic pontine glioma: a report of the children’s oncology group dipg preclinical consortium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862411/
https://www.ncbi.nlm.nih.gov/pubmed/25939062
http://dx.doi.org/10.1038/nm.3855
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