Cargando…

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

Two Plasmodium PI4 kinase (PI4K) inhibitors, KDU691 and LMV599, were selected for in vivo testing as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques, based on their in vitro activity against liver stages. Animals were infected with P. cynomolg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862498/ https://www.ncbi.nlm.nih.gov/pubmed/26926645 http://dx.doi.org/10.1128/AAC.03080-15

Ejemplares similares

Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage Parasites
por: Voorberg-van der Wel, Annemarie, et al.
Publicado: (2023)

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation
por: Voorberg-van der Wel, Annemarie M., et al.
Publicado: (2020)

Dual-Luciferase-Based Fast and Sensitive Detection of Malaria Hypnozoites for the Discovery of Antirelapse Compounds
por: Voorberg-van der Wel, Annemarie M., et al.
Publicado: (2020)

Modeling Relapsing Malaria: Emerging Technologies to Study Parasite-Host Interactions in the Liver
por: Voorberg-van der Wel, Annemarie, et al.
Publicado: (2021)

KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro
por: Zeeman, Anne-Marie, et al.
Publicado: (2014)

Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-Forms
por: Voorberg-van der Wel, Annemarie, et al.
Publicado: (2013)

Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi
por: Mitchell, Gabriel, et al.
Publicado: (2022)

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy
por: Bertschi, Nicole L, et al.
Publicado: (2018)

Sterile protection against relapsing malaria with a single-shot vaccine
por: Pasini, Erica M., et al.
Publicado: (2022)

An improved Plasmodium cynomolgi genome assembly reveals an unexpected methyltransferase gene expansion
por: Pasini, Erica M, et al.
Publicado: (2017)

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
por: Lakshminarayana, Suresh B., et al.
Publicado: (2015)

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi
por: Voorberg-van der Wel, Annemarie, et al.
Publicado: (2017)

The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development
por: Gupta, Devendra Kumar, et al.
Publicado: (2019)

Emergence of Plasmodium vivax Resistance to Chloroquine in French Guiana
por: Musset, Lise, et al.
Publicado: (2019)

Antibody Responses to a Novel Plasmodium falciparum Merozoite Surface Protein Vaccine Correlate with Protection against Experimental Malaria Infection in Aotus Monkeys
por: Cavanagh, David R., et al.
Publicado: (2014)

Prophylactic and Curative Inoculations
Publicado: (1900)

On Prophylactic and Curative Syphilization
Publicado: (1853)

Humoral Immune Responses to a Single Allele PfAMA1 Vaccine in Healthy Malaria-Naïve Adults
por: Remarque, Edmond J., et al.
Publicado: (2012)

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers
por: Leong, F. Joel, et al.
Publicado: (2014)

Insights into the association of ACEIs/ARBs use and COVID-19 prognosis: a multistate modelling study of nationwide hospital surveillance data from Belgium
por: Peñalvo, José L., et al.
Publicado: (2021)

Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia
por: Miesel, Lynn, et al.
Publicado: (2021)

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers
por: Leong, F. Joel, et al.
Publicado: (2014)

Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection
por: Fu, Yi-Peng, et al.
Publicado: (2016)

Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax
por: Ferreira, Letícia Tiburcio, et al.
Publicado: (2020)

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease
por: Francisco, Amanda Fortes, et al.
Publicado: (2018)

Parasite-Host Interaction and Pathophysiology Studies of the Human Relapsing Malarias Plasmodium vivax and Plasmodium ovale Infections in Non-Human Primates
por: Pasini, Erica M., et al.
Publicado: (2021)

In Vivo Curative and Protective Potential of Orally Administered 5-Aminolevulinic Acid plus Ferrous Ion against Malaria
por: Suzuki, Shigeo, et al.
Publicado: (2015)

Paludrine (Proguanil) as a Suppressive and Prophylactic in P.-Vivax Infections
por: Desai, V. G.
Publicado: (1951)

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
por: Kuhen, Kelli L., et al.
Publicado: (2014)

Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
por: Xue, H, et al.
Publicado: (2009)

Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
por: Holloway, Alex J., et al.
Publicado: (2019)

The presence of a systemic inflammatory response predicts poorer survival in patients receiving adjuvant 5-FU chemotherapy following potentially curative resection for colorectal cancer
por: Crozier, J E M, et al.
Publicado: (2006)

The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study
por: Bruynzeel, A M E, et al.
Publicado: (2007)

Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection
por: Zoula, S, et al.
Publicado: (2003)

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
por: Duiker, E W, et al.
Publicado: (2011)

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI
por: Gambarota, G, et al.
Publicado: (2008)

Clarity and applicability of adverse drug reaction-related monitoring instructions in clinical practice guidelines for children and adolescents treated with antipsychotic drugs: a review of six clinical practice guidelines
por: Minjon, Lenneke, et al.
Publicado: (2022)

From marginal to essential: the golden thread between nutrient sensing, medium composition and Plasmodium vivax maturation in in vitro culture
por: Thomson-Luque, Richard, et al.
Publicado: (2019)

Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis
por: Bicanic, Tihana, et al.
Publicado: (2015)

Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients
por: Franken, Linda G., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g577t33toiqlqf6o9lrsbcgrs5