NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines including IL-1β and IL-18. We show that NLRP3 inflammasome activation is restricted to interphase of the cell cycle by NEK7, a serine/threonine kinase previously implicated in mitosi...

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Detalles Bibliográficos
Autores principales: Shi, Hexin, Wang, Ying, Li, Xiaohong, Zhan, Xiaoming, Tan, Miao, Fina, Maggy, Su, Lijing, Pratt, David, Bu, Chun Hui, Hildebrand, Sara, Lyon, Stephen, Scott, Lindsay, Quan, Jiexia, Sun, Qihua, Russell, Jamie, Arnett, Stephanie, Jurek, Peter, Chen, Ding, Kravchenko, Vladimir V., Mathison, John C., Moresco, Eva Marie Y., Monson, Nancy L., Ulevitch, Richard J., Beutler, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862588/
https://www.ncbi.nlm.nih.gov/pubmed/26642356
http://dx.doi.org/10.1038/ni.3333

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