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Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors

The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal...

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Detalles Bibliográficos
Autores principales:	Yamagishi, Tetsuro, Kawashima, Hiroyuki, Ogose, Akira, Ariizumi, Takashi, Sasaki, Taro, Hatano, Hiroshi, Hotta, Tetsuo, Endo, Naoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862691/ https://www.ncbi.nlm.nih.gov/pubmed/27163152 http://dx.doi.org/10.1371/journal.pone.0154680

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