A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T cells expressing a highly diverse self-MHC restricted TCR repert...

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Detalles Bibliográficos
Autores principales: Feng, Yongqiang, van der Veeken, Joris, Shugay, Mikhail, Putintseva, Ekaterina V, Osmanbeyoglu, Hatice U, Dikiy, Stanislav, Hoyos, Beatrice E, Moltedo, Bruno, Hemmers, Saskia, Treuting, Piper, Leslie, Christina S, Chudakov, Dmitriy M, Rudensky, Alexander Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862833/
https://www.ncbi.nlm.nih.gov/pubmed/26605529
http://dx.doi.org/10.1038/nature16141

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