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Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats

Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the blood stream and their estimation is a quantitative marker for the extent of damage. The cytoprotective...

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Autores principales: Aseervatham, Jaya, Palanivelu, Shanthi, Sachdanandam, Panchanadham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863295/
https://www.ncbi.nlm.nih.gov/pubmed/27186099
http://dx.doi.org/10.2147/JEP.S11466
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author Aseervatham, Jaya
Palanivelu, Shanthi
Sachdanandam, Panchanadham
author_facet Aseervatham, Jaya
Palanivelu, Shanthi
Sachdanandam, Panchanadham
author_sort Aseervatham, Jaya
collection PubMed
description Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the blood stream and their estimation is a quantitative marker for the extent of damage. The cytoprotective effect of Semecarpus anacardium was evaluated in rats that were rendered diabetic by administration of streptozotocin at a dose of 50 mg/kg body weight. The activities of the marker enzymes were assayed in the serum, liver and kidney. The indicators of renal damage such as urea, uric acid and creatinine were assayed in addition to the blood profile. The results of the present study reveal that Semecarpus anacardium was able to reverse the levels of the marker enzymes, and protect the kidney by reverting back to the normal levels of urea, uric acid, and creatinine. The abnormal blood parameters were also reverted to near normal levels indicating the drug’s cytoprotective effect.
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spelling pubmed-48632952016-05-16 Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats Aseervatham, Jaya Palanivelu, Shanthi Sachdanandam, Panchanadham J Exp Pharmacol Original Research Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the blood stream and their estimation is a quantitative marker for the extent of damage. The cytoprotective effect of Semecarpus anacardium was evaluated in rats that were rendered diabetic by administration of streptozotocin at a dose of 50 mg/kg body weight. The activities of the marker enzymes were assayed in the serum, liver and kidney. The indicators of renal damage such as urea, uric acid and creatinine were assayed in addition to the blood profile. The results of the present study reveal that Semecarpus anacardium was able to reverse the levels of the marker enzymes, and protect the kidney by reverting back to the normal levels of urea, uric acid, and creatinine. The abnormal blood parameters were also reverted to near normal levels indicating the drug’s cytoprotective effect. Dove Medical Press 2010-08-25 /pmc/articles/PMC4863295/ /pubmed/27186099 http://dx.doi.org/10.2147/JEP.S11466 Text en © 2010 Aseervatham et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Aseervatham, Jaya
Palanivelu, Shanthi
Sachdanandam, Panchanadham
Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title_full Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title_fullStr Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title_full_unstemmed Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title_short Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats
title_sort cytoprotective effect of semecarpus anacardium against toxicity induced by streptozotocin in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863295/
https://www.ncbi.nlm.nih.gov/pubmed/27186099
http://dx.doi.org/10.2147/JEP.S11466
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