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Clevidipine resistance in a patient taking aripiprazole and methylphenidate
Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium channel antagonist of the dihydropyridine clas...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863534/ https://www.ncbi.nlm.nih.gov/pubmed/27186138 http://dx.doi.org/10.2147/JEP.S71914 |
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author | Jacklen, M Alysse Campagna, Jason A Tobias, Joseph D |
author_facet | Jacklen, M Alysse Campagna, Jason A Tobias, Joseph D |
author_sort | Jacklen, M Alysse |
collection | PubMed |
description | Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium channel antagonist of the dihydropyridine class. Anecdotal experience has demonstrated its efficacy in various clinical scenarios in the pediatric population. We report apparent resistance to the vasodilatory effects of clevidipine in a 13-year-old girl who presented for anesthetic care during posterior spinal fusion for neuromuscular scoliosis whose chronic medication regimen included aripiprazole and methylphenidate for the treatment of depression and attention-deficit/hyperactivity disorder. We discuss the potential interaction of aripiprazole and methylphenidate with the calcium channel antagonists and cellular mechanisms responsible for the resistance to the vasodilatory effects of clevidipine. |
format | Online Article Text |
id | pubmed-4863534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48635342016-05-16 Clevidipine resistance in a patient taking aripiprazole and methylphenidate Jacklen, M Alysse Campagna, Jason A Tobias, Joseph D J Exp Pharmacol Case Report Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium channel antagonist of the dihydropyridine class. Anecdotal experience has demonstrated its efficacy in various clinical scenarios in the pediatric population. We report apparent resistance to the vasodilatory effects of clevidipine in a 13-year-old girl who presented for anesthetic care during posterior spinal fusion for neuromuscular scoliosis whose chronic medication regimen included aripiprazole and methylphenidate for the treatment of depression and attention-deficit/hyperactivity disorder. We discuss the potential interaction of aripiprazole and methylphenidate with the calcium channel antagonists and cellular mechanisms responsible for the resistance to the vasodilatory effects of clevidipine. Dove Medical Press 2014-10-17 /pmc/articles/PMC4863534/ /pubmed/27186138 http://dx.doi.org/10.2147/JEP.S71914 Text en © 2014 Jacklen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Jacklen, M Alysse Campagna, Jason A Tobias, Joseph D Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title | Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title_full | Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title_fullStr | Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title_full_unstemmed | Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title_short | Clevidipine resistance in a patient taking aripiprazole and methylphenidate |
title_sort | clevidipine resistance in a patient taking aripiprazole and methylphenidate |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863534/ https://www.ncbi.nlm.nih.gov/pubmed/27186138 http://dx.doi.org/10.2147/JEP.S71914 |
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