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Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact su...

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Autores principales: Abner, Erin L., Jicha, Gregory A., Shaw, Leslie M., Trojanowski, John Q., Goetzl, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863753/
https://www.ncbi.nlm.nih.gov/pubmed/27231710
http://dx.doi.org/10.1002/acn3.309
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author Abner, Erin L.
Jicha, Gregory A.
Shaw, Leslie M.
Trojanowski, John Q.
Goetzl, Edward J.
author_facet Abner, Erin L.
Jicha, Gregory A.
Shaw, Leslie M.
Trojanowski, John Q.
Goetzl, Edward J.
author_sort Abner, Erin L.
collection PubMed
description Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P‐T181‐tau, P‐S396‐tau, Aβ (1‐42), cathepsin D, repressor element 1‐silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3‐ to 11‐year intervals. Except for P‐S396‐tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.
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spelling pubmed-48637532016-05-26 Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging Abner, Erin L. Jicha, Gregory A. Shaw, Leslie M. Trojanowski, John Q. Goetzl, Edward J. Ann Clin Transl Neurol Brief Communications Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P‐T181‐tau, P‐S396‐tau, Aβ (1‐42), cathepsin D, repressor element 1‐silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3‐ to 11‐year intervals. Except for P‐S396‐tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients. John Wiley and Sons Inc. 2016-04-13 /pmc/articles/PMC4863753/ /pubmed/27231710 http://dx.doi.org/10.1002/acn3.309 Text en © 2016 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Abner, Erin L.
Jicha, Gregory A.
Shaw, Leslie M.
Trojanowski, John Q.
Goetzl, Edward J.
Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title_full Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title_fullStr Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title_full_unstemmed Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title_short Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
title_sort plasma neuronal exosomal levels of alzheimer's disease biomarkers in normal aging
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863753/
https://www.ncbi.nlm.nih.gov/pubmed/27231710
http://dx.doi.org/10.1002/acn3.309
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