Loss of MAPK Pathway Activation in Post-Mitotic Retinal Cells as Mechanism in MEK Inhibition-Related Retinopathy in Cancer Patients

Recently, treatment with MEK inhibitors has been shown to be an effective treatment option for metastatic melanoma. Treatment efficacy is dependent on inhibition of MAPK-related melanoma proliferation. However, targeting of MEK can be accompanied by a time-dependent and reversible serous retinopathy...

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Detalles Bibliográficos
Autores principales: van Dijk, Elon H. C., Duits, Danique E. M., Versluis, Mieke, Luyten, Gregrorius P. M., Bergen, Arthur A. B., Kapiteijn, Ellen W., de Lange, Mark J., Boon, Camiel J. F., van der Velden, Pieter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
5800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863761/
https://www.ncbi.nlm.nih.gov/pubmed/27149444
http://dx.doi.org/10.1097/MD.0000000000003457

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