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A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage
OBJECTIVES: To assess the clinical relevance of T(2) relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T(2)-mapping. METHODS: Thirteen volunteers and ten patients with focal cartilage lesions were included i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863907/ https://www.ncbi.nlm.nih.gov/pubmed/26334512 http://dx.doi.org/10.1007/s00330-015-3979-6 |
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author | Juras, Vladimir Bohndorf, Klaus Heule, Rahel Kronnerwetter, Claudia Szomolanyi, Pavol Hager, Benedikt Bieri, Oliver Zbyn, Stefan Trattnig, Siegfried |
author_facet | Juras, Vladimir Bohndorf, Klaus Heule, Rahel Kronnerwetter, Claudia Szomolanyi, Pavol Hager, Benedikt Bieri, Oliver Zbyn, Stefan Trattnig, Siegfried |
author_sort | Juras, Vladimir |
collection | PubMed |
description | OBJECTIVES: To assess the clinical relevance of T(2) relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T(2)-mapping. METHODS: Thirteen volunteers and ten patients with focal cartilage lesions were included in this prospective study. All subjects underwent 3-Tesla MRI consisting of a multi-echo multi-slice spin-echo sequence (CPMG) as a reference method for T(2) mapping, and 3D TESS with the same geometry settings, but variable acquisition times: standard (TESSs 4:35min) and quick (TESSq 2:05min). T(2) values were compared in six different regions in the femoral and tibial cartilage using a Wilcoxon signed ranks test and the Pearson correlation coefficient (r). The local ethics committee approved this study, and all participants gave written informed consent. RESULTS: The mean quantitative T(2) values measured by CPMG (mean: 46±9ms) in volunteers were significantly higher compared to those measured with TESS (mean: 31±5ms) in all regions. Both methods performed similarly in patients, but CPMG provided a slightly higher difference between lesions and native cartilage (CPMG: 90ms→61ms [31%],p=0.0125;TESS 32ms→24ms [24%],p=0.0839). CONCLUSIONS: 3D-TESS provides results similar to those of a conventional multi-echo spin-echo sequence with many benefits, such as shortening of total acquisition time and insensitivity to B(1) and B(0) changes. KEY POINTS: • 3D-TESS T(2)mapping provides clinically comparable results to CPMG in shorter scan-time. • Clinical and investigational studies may benefit from high temporal resolution of 3D-TESS. • 3D-TESS T(2)values are able to differentiate between healthy and damaged cartilage. |
format | Online Article Text |
id | pubmed-4863907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-48639072016-05-25 A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage Juras, Vladimir Bohndorf, Klaus Heule, Rahel Kronnerwetter, Claudia Szomolanyi, Pavol Hager, Benedikt Bieri, Oliver Zbyn, Stefan Trattnig, Siegfried Eur Radiol Magnetic Resonance OBJECTIVES: To assess the clinical relevance of T(2) relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T(2)-mapping. METHODS: Thirteen volunteers and ten patients with focal cartilage lesions were included in this prospective study. All subjects underwent 3-Tesla MRI consisting of a multi-echo multi-slice spin-echo sequence (CPMG) as a reference method for T(2) mapping, and 3D TESS with the same geometry settings, but variable acquisition times: standard (TESSs 4:35min) and quick (TESSq 2:05min). T(2) values were compared in six different regions in the femoral and tibial cartilage using a Wilcoxon signed ranks test and the Pearson correlation coefficient (r). The local ethics committee approved this study, and all participants gave written informed consent. RESULTS: The mean quantitative T(2) values measured by CPMG (mean: 46±9ms) in volunteers were significantly higher compared to those measured with TESS (mean: 31±5ms) in all regions. Both methods performed similarly in patients, but CPMG provided a slightly higher difference between lesions and native cartilage (CPMG: 90ms→61ms [31%],p=0.0125;TESS 32ms→24ms [24%],p=0.0839). CONCLUSIONS: 3D-TESS provides results similar to those of a conventional multi-echo spin-echo sequence with many benefits, such as shortening of total acquisition time and insensitivity to B(1) and B(0) changes. KEY POINTS: • 3D-TESS T(2)mapping provides clinically comparable results to CPMG in shorter scan-time. • Clinical and investigational studies may benefit from high temporal resolution of 3D-TESS. • 3D-TESS T(2)values are able to differentiate between healthy and damaged cartilage. Springer Berlin Heidelberg 2015-09-03 2016 /pmc/articles/PMC4863907/ /pubmed/26334512 http://dx.doi.org/10.1007/s00330-015-3979-6 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Magnetic Resonance Juras, Vladimir Bohndorf, Klaus Heule, Rahel Kronnerwetter, Claudia Szomolanyi, Pavol Hager, Benedikt Bieri, Oliver Zbyn, Stefan Trattnig, Siegfried A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title | A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title_full | A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title_fullStr | A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title_full_unstemmed | A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title_short | A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage |
title_sort | comparison of multi-echo spin-echo and triple-echo steady-state t2 mapping for in vivo evaluation of articular cartilage |
topic | Magnetic Resonance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863907/ https://www.ncbi.nlm.nih.gov/pubmed/26334512 http://dx.doi.org/10.1007/s00330-015-3979-6 |
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