The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway

Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme involved in tumor malignancy. However, the regulatory mechanism underlying its involvement remains largely uncharacterized. The present study aimed to investigate the hypothesis that NK4, an antagonist of hepatocyte growth factor (HGF)...

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Detalles Bibliográficos
Autores principales: WANG, DONGDONG, SAGA, YASUSHI, SATO, NAOTO, NAKAMURA, TOSHIKAZU, TAKIKAWA, OSAMU, MIZUKAMI, HIROAKI, MATSUBARA, SHIGEKI, FUJIWARA, HIROYUKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863924/
https://www.ncbi.nlm.nih.gov/pubmed/27082119
http://dx.doi.org/10.3892/ijo.2016.3486

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