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Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines

Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 cells, CM101 selectively inhibited DNA binding by overexpressed NF-κ...

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Detalles Bibliográficos
Autores principales:	Yeo, Alan T., Chennamadhavuni, Spandan, Whitty, Adrian, Porco, John A., Gilmore, Thomas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863944/ https://www.ncbi.nlm.nih.gov/pubmed/25915462 http://dx.doi.org/10.3390/molecules20057474

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