Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular malformations that cause stroke and seizures in younger individuals(1). CCMs arise from endothelial cell loss of KRIT1, CCM2, or PDCD10, non-homologous proteins that form an adaptor complex(2). How disruption of the C...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864035/
https://www.ncbi.nlm.nih.gov/pubmed/27027284
http://dx.doi.org/10.1038/nature17178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864035/
https://www.ncbi.nlm.nih.gov/pubmed/27027284
http://dx.doi.org/10.1038/nature17178

Ejemplares similares