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Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling
Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular malformations that cause stroke and seizures in younger individuals(1). CCMs arise from endothelial cell loss of KRIT1, CCM2, or PDCD10, non-homologous proteins that form an adaptor complex(2). How disruption of the C...
Autores principales: | Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864035/ https://www.ncbi.nlm.nih.gov/pubmed/27027284 http://dx.doi.org/10.1038/nature17178 |
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