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Epigenome-modifying tools in asthma

Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, m...

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Detalles Bibliográficos
Autores principales: Brook, Peter O, Perry, Mark M, Adcock, Ian M, Durham, Andrew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864050/
https://www.ncbi.nlm.nih.gov/pubmed/26479310
http://dx.doi.org/10.2217/epi.15.53
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author Brook, Peter O
Perry, Mark M
Adcock, Ian M
Durham, Andrew L
author_facet Brook, Peter O
Perry, Mark M
Adcock, Ian M
Durham, Andrew L
author_sort Brook, Peter O
collection PubMed
description Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.
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spelling pubmed-48640502016-07-25 Epigenome-modifying tools in asthma Brook, Peter O Perry, Mark M Adcock, Ian M Durham, Andrew L Epigenomics Review Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention. Future Medicine Ltd 2015-09 /pmc/articles/PMC4864050/ /pubmed/26479310 http://dx.doi.org/10.2217/epi.15.53 Text en © P Brook This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Brook, Peter O
Perry, Mark M
Adcock, Ian M
Durham, Andrew L
Epigenome-modifying tools in asthma
title Epigenome-modifying tools in asthma
title_full Epigenome-modifying tools in asthma
title_fullStr Epigenome-modifying tools in asthma
title_full_unstemmed Epigenome-modifying tools in asthma
title_short Epigenome-modifying tools in asthma
title_sort epigenome-modifying tools in asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864050/
https://www.ncbi.nlm.nih.gov/pubmed/26479310
http://dx.doi.org/10.2217/epi.15.53
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