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Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance

Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor. The role of chemerin and CMKLR1 in inflammato...

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Autores principales: Corona-Meraz, Fernanda-Isadora, Navarro-Hernández, Rosa-Elena, Ruíz-Quezada, Sandra-Luz, Madrigal-Ruíz, Perla-Monserrat, Castro-Albarrán, Jorge, Chavarría-Ávila, Efraín, Guzmán-Ornelas, Milton-Omar, Gómez-Bañuelos, Eduardo, Petri, Marcelo-Herón, Ramírez-Cedano, Joel-Isidro, Aguilar-Aldrete, María-Elena, Ríos-Ibarra, Clara, Vázquez-Del Mercado, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864190/
https://www.ncbi.nlm.nih.gov/pubmed/27239101
http://dx.doi.org/10.1155/2016/3085390
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author Corona-Meraz, Fernanda-Isadora
Navarro-Hernández, Rosa-Elena
Ruíz-Quezada, Sandra-Luz
Madrigal-Ruíz, Perla-Monserrat
Castro-Albarrán, Jorge
Chavarría-Ávila, Efraín
Guzmán-Ornelas, Milton-Omar
Gómez-Bañuelos, Eduardo
Petri, Marcelo-Herón
Ramírez-Cedano, Joel-Isidro
Aguilar-Aldrete, María-Elena
Ríos-Ibarra, Clara
Vázquez-Del Mercado, Mónica
author_facet Corona-Meraz, Fernanda-Isadora
Navarro-Hernández, Rosa-Elena
Ruíz-Quezada, Sandra-Luz
Madrigal-Ruíz, Perla-Monserrat
Castro-Albarrán, Jorge
Chavarría-Ávila, Efraín
Guzmán-Ornelas, Milton-Omar
Gómez-Bañuelos, Eduardo
Petri, Marcelo-Herón
Ramírez-Cedano, Joel-Isidro
Aguilar-Aldrete, María-Elena
Ríos-Ibarra, Clara
Vázquez-Del Mercado, Mónica
author_sort Corona-Meraz, Fernanda-Isadora
collection PubMed
description Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor. The role of chemerin and CMKLR1 in inflammatory process secondary to obesity is not defined yet. Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression of CMKLR1 were evaluated with qPCR and 2(−ΔΔC(T)) method. Results. Differences (P < 0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. Both CMKLR1 expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r = 8.8% to 38.5%), P < 0.05. Conclusion. The increment of CMKLR1 expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
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spelling pubmed-48641902016-05-29 Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance Corona-Meraz, Fernanda-Isadora Navarro-Hernández, Rosa-Elena Ruíz-Quezada, Sandra-Luz Madrigal-Ruíz, Perla-Monserrat Castro-Albarrán, Jorge Chavarría-Ávila, Efraín Guzmán-Ornelas, Milton-Omar Gómez-Bañuelos, Eduardo Petri, Marcelo-Herón Ramírez-Cedano, Joel-Isidro Aguilar-Aldrete, María-Elena Ríos-Ibarra, Clara Vázquez-Del Mercado, Mónica Mediators Inflamm Research Article Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor. The role of chemerin and CMKLR1 in inflammatory process secondary to obesity is not defined yet. Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression of CMKLR1 were evaluated with qPCR and 2(−ΔΔC(T)) method. Results. Differences (P < 0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. Both CMKLR1 expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r = 8.8% to 38.5%), P < 0.05. Conclusion. The increment of CMKLR1 expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR. Hindawi Publishing Corporation 2016 2016-04-28 /pmc/articles/PMC4864190/ /pubmed/27239101 http://dx.doi.org/10.1155/2016/3085390 Text en Copyright © 2016 Fernanda-Isadora Corona-Meraz et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Corona-Meraz, Fernanda-Isadora
Navarro-Hernández, Rosa-Elena
Ruíz-Quezada, Sandra-Luz
Madrigal-Ruíz, Perla-Monserrat
Castro-Albarrán, Jorge
Chavarría-Ávila, Efraín
Guzmán-Ornelas, Milton-Omar
Gómez-Bañuelos, Eduardo
Petri, Marcelo-Herón
Ramírez-Cedano, Joel-Isidro
Aguilar-Aldrete, María-Elena
Ríos-Ibarra, Clara
Vázquez-Del Mercado, Mónica
Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title_full Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title_fullStr Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title_full_unstemmed Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title_short Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
title_sort inverse relationship of the cmklr1 relative expression and chemerin serum levels in obesity with dysmetabolic phenotype and insulin resistance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864190/
https://www.ncbi.nlm.nih.gov/pubmed/27239101
http://dx.doi.org/10.1155/2016/3085390
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