Could Digital PCR Be an Alternative as a Non-Invasive Prenatal Test for Trisomy 21: A Proof of Concept Study

OBJECTIVE: NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions needed to meet statistical requirements, preventing clinical application. Here, we designed an octoplex droplet digital PCR (ddPCR) assay which allows increasing the number of available targets...

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Detalles Bibliográficos
Autores principales: El Khattabi, Laïla Allach, Rouillac-Le Sciellour, Christelle, Le Tessier, Dominique, Luscan, Armelle, Coustier, Audrey, Porcher, Raphael, Bhouri, Rakia, Nectoux, Juliette, Sérazin, Valérie, Quibel, Thibaut, Mandelbrot, Laurent, Tsatsaris, Vassilis, Vialard, François, Dupont, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864235/
https://www.ncbi.nlm.nih.gov/pubmed/27167625
http://dx.doi.org/10.1371/journal.pone.0155009

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