Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects

Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more...

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Autores principales: Reinartz, Susanne M., van Tongeren, Joost, van Egmond, Danielle, de Groot, Esther J. J., Fokkens, Wytske J., van Drunen, Cornelis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864364/
https://www.ncbi.nlm.nih.gov/pubmed/27166951
http://dx.doi.org/10.1371/journal.pone.0154409
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author Reinartz, Susanne M.
van Tongeren, Joost
van Egmond, Danielle
de Groot, Esther J. J.
Fokkens, Wytske J.
van Drunen, Cornelis M.
author_facet Reinartz, Susanne M.
van Tongeren, Joost
van Egmond, Danielle
de Groot, Esther J. J.
Fokkens, Wytske J.
van Drunen, Cornelis M.
author_sort Reinartz, Susanne M.
collection PubMed
description Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.
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spelling pubmed-48643642016-05-18 Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects Reinartz, Susanne M. van Tongeren, Joost van Egmond, Danielle de Groot, Esther J. J. Fokkens, Wytske J. van Drunen, Cornelis M. PLoS One Research Article Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status. Public Library of Science 2016-05-11 /pmc/articles/PMC4864364/ /pubmed/27166951 http://dx.doi.org/10.1371/journal.pone.0154409 Text en © 2016 Reinartz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Reinartz, Susanne M.
van Tongeren, Joost
van Egmond, Danielle
de Groot, Esther J. J.
Fokkens, Wytske J.
van Drunen, Cornelis M.
Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title_full Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title_fullStr Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title_full_unstemmed Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title_short Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
title_sort dendritic cell subsets in oral mucosa of allergic and healthy subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864364/
https://www.ncbi.nlm.nih.gov/pubmed/27166951
http://dx.doi.org/10.1371/journal.pone.0154409
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