Cargando…
Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan
The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common caro...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864369/ https://www.ncbi.nlm.nih.gov/pubmed/27169625 http://dx.doi.org/10.1038/srep25733 |
_version_ | 1782431617219821568 |
---|---|
author | Chen, Pei-Chun Jeng, Jiann-Shing Hsu, Hsiu-Ching Su, Ta-Chen Chien, Kuo-Liong Lee, Yuan-Teh |
author_facet | Chen, Pei-Chun Jeng, Jiann-Shing Hsu, Hsiu-Ching Su, Ta-Chen Chien, Kuo-Liong Lee, Yuan-Teh |
author_sort | Chen, Pei-Chun |
collection | PubMed |
description | The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common carotid artery intima-media thickness (IMT) and extracranial carotid artery plaque score at both 1994–1995 and 1999–2000 surveys. Cox proportional hazards model was used to assess the risk of incident cardiovascular disease. During a median follow-up of 13 years (1999–2013), 71 strokes and 68 coronary events occurred. The 5-year individual IMT change was not associated with development of cardiovascular events in unadjusted and adjusted models. Among subjects without plaque in 1994–1995, we observed elevated risk associated with presence of new plaque (plaque score >0 in 1999–2000) in a dose-response manner in unadjusted and age- and sex- adjusted models. The associations attenuated and became statistically non-significant after controlling for cardiovascular risk factors (hazard ratio [95% confidence interval] for plaque score >2 vs. 0: stroke, 1.61 [0.79–3.27], coronary events, 1.13 [0.48–2.69]). This study suggested that carotid plaque formation measured by ultrasound is associated increased risk of developing cardiovascular disease, and cardiovascular risk factors explain the associations to a large extent. |
format | Online Article Text |
id | pubmed-4864369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48643692016-05-23 Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan Chen, Pei-Chun Jeng, Jiann-Shing Hsu, Hsiu-Ching Su, Ta-Chen Chien, Kuo-Liong Lee, Yuan-Teh Sci Rep Article The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common carotid artery intima-media thickness (IMT) and extracranial carotid artery plaque score at both 1994–1995 and 1999–2000 surveys. Cox proportional hazards model was used to assess the risk of incident cardiovascular disease. During a median follow-up of 13 years (1999–2013), 71 strokes and 68 coronary events occurred. The 5-year individual IMT change was not associated with development of cardiovascular events in unadjusted and adjusted models. Among subjects without plaque in 1994–1995, we observed elevated risk associated with presence of new plaque (plaque score >0 in 1999–2000) in a dose-response manner in unadjusted and age- and sex- adjusted models. The associations attenuated and became statistically non-significant after controlling for cardiovascular risk factors (hazard ratio [95% confidence interval] for plaque score >2 vs. 0: stroke, 1.61 [0.79–3.27], coronary events, 1.13 [0.48–2.69]). This study suggested that carotid plaque formation measured by ultrasound is associated increased risk of developing cardiovascular disease, and cardiovascular risk factors explain the associations to a large extent. Nature Publishing Group 2016-05-12 /pmc/articles/PMC4864369/ /pubmed/27169625 http://dx.doi.org/10.1038/srep25733 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Chen, Pei-Chun Jeng, Jiann-Shing Hsu, Hsiu-Ching Su, Ta-Chen Chien, Kuo-Liong Lee, Yuan-Teh Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title_full | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title_fullStr | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title_full_unstemmed | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title_short | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan |
title_sort | carotid atherosclerosis progression and risk of cardiovascular events in a community in taiwan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864369/ https://www.ncbi.nlm.nih.gov/pubmed/27169625 http://dx.doi.org/10.1038/srep25733 |
work_keys_str_mv | AT chenpeichun carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan AT jengjiannshing carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan AT hsuhsiuching carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan AT sutachen carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan AT chienkuoliong carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan AT leeyuanteh carotidatherosclerosisprogressionandriskofcardiovasculareventsinacommunityintaiwan |