Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy

Dramatic genome dynamics, such as chromosome instability, contribute to the remarkable genomic heterogeneity among the blastomeres comprising a single embryo during human preimplantation development. This heterogeneity, when compatible with life, manifests as constitutional mosaicism, chimerism, and...

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Detalles Bibliográficos
Autores principales: Destouni, Aspasia, Zamani Esteki, Masoud, Catteeuw, Maaike, Tšuiko, Olga, Dimitriadou, Eftychia, Smits, Katrien, Kurg, Ants, Salumets, Andres, Van Soom, Ann, Voet, Thierry, Vermeesch, Joris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864459/
https://www.ncbi.nlm.nih.gov/pubmed/27197242
http://dx.doi.org/10.1101/gr.200527.115

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