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CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1

Bacterial LPS is an environmental toxin capable of promoting various cardiac complications. Current evidence suggests that LPS-induced myocardial dysfunction emerges as a consequence of compromised quality of cardiac mitochondria. Docosahexaenoic acid (DHA, 22:6n3) is an n-3 polyunsaturated fatty ac...

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Detalles Bibliográficos
Autores principales:	Samokhvalov, V, Jamieson, K L, Vriend, J, Quan, S, Seubert, J M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864499/ https://www.ncbi.nlm.nih.gov/pubmed/27182450 http://dx.doi.org/10.1038/cddiscovery.2015.54

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