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Plasma Cytokine Profiles in Long-Term Strenuous Exercise

The open window theory indicates altered immunity 3 to 72 hours after exercise. The J-curve describes the risk of illness in response to exercise. The aim of this study was to examine the secretion of proinflammatory and anti-inflammatory cytokines before and after long-term strenuous exercise. Four...

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Autores principales: Nielsen, Hilde G., Øktedalen, Olav, Opstad, Per-Kristian, Lyberg, Torstein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864530/
https://www.ncbi.nlm.nih.gov/pubmed/27239554
http://dx.doi.org/10.1155/2016/7186137
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author Nielsen, Hilde G.
Øktedalen, Olav
Opstad, Per-Kristian
Lyberg, Torstein
author_facet Nielsen, Hilde G.
Øktedalen, Olav
Opstad, Per-Kristian
Lyberg, Torstein
author_sort Nielsen, Hilde G.
collection PubMed
description The open window theory indicates altered immunity 3 to 72 hours after exercise. The J-curve describes the risk of illness in response to exercise. The aim of this study was to examine the secretion of proinflammatory and anti-inflammatory cytokines before and after long-term strenuous exercise. Fourteen marathon and 16 half-marathon runners and 10 military cadets participating in a military ranger-training course were recruited to this study. Within-subject design was used measuring levels of plasma cytokines before, during, and after exercise. Plasma cytokines were measured using Luminex multiplex technology and ELISA. Comparing pre/post plasma levels both the marathon- and the half-marathon runners showed heavily increased levels of IL-6, IL-10, and IL-8 (P < 0.001). LPS stimulation among the half-marathon runners decreased the postrace levels of IL-6, IL-1b, and TNFα by 45%, 24%, and 43%, respectively (P < 0.01). During the ranger training course the spontaneous and LPS-stimulated levels of IL-6, IL-8, IL-10, IL-1b, and TNFα changed in a similar fashion as in the half-marathon runners although the fluctuations were smaller. Our study supports the open window and the J-curve theory; the immune system is more activated and the subjects are more threatened to infectious pathogens after intensive physical activity and in the period after exercise.
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spelling pubmed-48645302016-05-29 Plasma Cytokine Profiles in Long-Term Strenuous Exercise Nielsen, Hilde G. Øktedalen, Olav Opstad, Per-Kristian Lyberg, Torstein J Sports Med (Hindawi Publ Corp) Research Article The open window theory indicates altered immunity 3 to 72 hours after exercise. The J-curve describes the risk of illness in response to exercise. The aim of this study was to examine the secretion of proinflammatory and anti-inflammatory cytokines before and after long-term strenuous exercise. Fourteen marathon and 16 half-marathon runners and 10 military cadets participating in a military ranger-training course were recruited to this study. Within-subject design was used measuring levels of plasma cytokines before, during, and after exercise. Plasma cytokines were measured using Luminex multiplex technology and ELISA. Comparing pre/post plasma levels both the marathon- and the half-marathon runners showed heavily increased levels of IL-6, IL-10, and IL-8 (P < 0.001). LPS stimulation among the half-marathon runners decreased the postrace levels of IL-6, IL-1b, and TNFα by 45%, 24%, and 43%, respectively (P < 0.01). During the ranger training course the spontaneous and LPS-stimulated levels of IL-6, IL-8, IL-10, IL-1b, and TNFα changed in a similar fashion as in the half-marathon runners although the fluctuations were smaller. Our study supports the open window and the J-curve theory; the immune system is more activated and the subjects are more threatened to infectious pathogens after intensive physical activity and in the period after exercise. Hindawi Publishing Corporation 2016 2016-04-28 /pmc/articles/PMC4864530/ /pubmed/27239554 http://dx.doi.org/10.1155/2016/7186137 Text en Copyright © 2016 Hilde G. Nielsen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nielsen, Hilde G.
Øktedalen, Olav
Opstad, Per-Kristian
Lyberg, Torstein
Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title_full Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title_fullStr Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title_full_unstemmed Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title_short Plasma Cytokine Profiles in Long-Term Strenuous Exercise
title_sort plasma cytokine profiles in long-term strenuous exercise
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864530/
https://www.ncbi.nlm.nih.gov/pubmed/27239554
http://dx.doi.org/10.1155/2016/7186137
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