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Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neura...

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Detalles Bibliográficos
Autores principales: Prajumwongs, Piya, Weeranantanapan, Oratai, Jaroonwitchawan, Thiranut, Noisa, Parinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864561/
https://www.ncbi.nlm.nih.gov/pubmed/27239201
http://dx.doi.org/10.1155/2016/2958210
Descripción
Sumario:Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.