Cargando…
Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neura...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864561/ https://www.ncbi.nlm.nih.gov/pubmed/27239201 http://dx.doi.org/10.1155/2016/2958210 |
_version_ | 1782431646232870912 |
---|---|
author | Prajumwongs, Piya Weeranantanapan, Oratai Jaroonwitchawan, Thiranut Noisa, Parinya |
author_facet | Prajumwongs, Piya Weeranantanapan, Oratai Jaroonwitchawan, Thiranut Noisa, Parinya |
author_sort | Prajumwongs, Piya |
collection | PubMed |
description | Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation. |
format | Online Article Text |
id | pubmed-4864561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48645612016-05-29 Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases Prajumwongs, Piya Weeranantanapan, Oratai Jaroonwitchawan, Thiranut Noisa, Parinya Stem Cells Int Review Article Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation. Hindawi Publishing Corporation 2016 2016-04-28 /pmc/articles/PMC4864561/ /pubmed/27239201 http://dx.doi.org/10.1155/2016/2958210 Text en Copyright © 2016 Piya Prajumwongs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Prajumwongs, Piya Weeranantanapan, Oratai Jaroonwitchawan, Thiranut Noisa, Parinya Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title | Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title_full | Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title_fullStr | Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title_full_unstemmed | Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title_short | Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases |
title_sort | human embryonic stem cells: a model for the study of neural development and neurological diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864561/ https://www.ncbi.nlm.nih.gov/pubmed/27239201 http://dx.doi.org/10.1155/2016/2958210 |
work_keys_str_mv | AT prajumwongspiya humanembryonicstemcellsamodelforthestudyofneuraldevelopmentandneurologicaldiseases AT weeranantanapanoratai humanembryonicstemcellsamodelforthestudyofneuraldevelopmentandneurologicaldiseases AT jaroonwitchawanthiranut humanembryonicstemcellsamodelforthestudyofneuraldevelopmentandneurologicaldiseases AT noisaparinya humanembryonicstemcellsamodelforthestudyofneuraldevelopmentandneurologicaldiseases |