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Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neura...

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Autores principales: Prajumwongs, Piya, Weeranantanapan, Oratai, Jaroonwitchawan, Thiranut, Noisa, Parinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864561/
https://www.ncbi.nlm.nih.gov/pubmed/27239201
http://dx.doi.org/10.1155/2016/2958210
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author Prajumwongs, Piya
Weeranantanapan, Oratai
Jaroonwitchawan, Thiranut
Noisa, Parinya
author_facet Prajumwongs, Piya
Weeranantanapan, Oratai
Jaroonwitchawan, Thiranut
Noisa, Parinya
author_sort Prajumwongs, Piya
collection PubMed
description Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.
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spelling pubmed-48645612016-05-29 Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases Prajumwongs, Piya Weeranantanapan, Oratai Jaroonwitchawan, Thiranut Noisa, Parinya Stem Cells Int Review Article Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation. Hindawi Publishing Corporation 2016 2016-04-28 /pmc/articles/PMC4864561/ /pubmed/27239201 http://dx.doi.org/10.1155/2016/2958210 Text en Copyright © 2016 Piya Prajumwongs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Prajumwongs, Piya
Weeranantanapan, Oratai
Jaroonwitchawan, Thiranut
Noisa, Parinya
Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title_full Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title_fullStr Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title_full_unstemmed Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title_short Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases
title_sort human embryonic stem cells: a model for the study of neural development and neurological diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864561/
https://www.ncbi.nlm.nih.gov/pubmed/27239201
http://dx.doi.org/10.1155/2016/2958210
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