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Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique
BACKGROUND: Pregabalin and gabapentin are the gamma-aminobutyric acid analogs used as a part of multimodal analgesic regimen. AIM: To compare the postoperative analgesic benefits of gabapentin or pregabalin as a premedication for lower limb orthopedic surgery under combined spinal-epidural technique...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864698/ https://www.ncbi.nlm.nih.gov/pubmed/27212758 http://dx.doi.org/10.4103/0259-1162.172339 |
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author | Khetarpal, Ranjana Kataria, Amar Parakash Bajaj, Samita Kaur, Harjinder Singh, Sudha |
author_facet | Khetarpal, Ranjana Kataria, Amar Parakash Bajaj, Samita Kaur, Harjinder Singh, Sudha |
author_sort | Khetarpal, Ranjana |
collection | PubMed |
description | BACKGROUND: Pregabalin and gabapentin are the gamma-aminobutyric acid analogs used as a part of multimodal analgesic regimen. AIM: To compare the postoperative analgesic benefits of gabapentin or pregabalin as a premedication for lower limb orthopedic surgery under combined spinal-epidural techniques. SETTINGS AND DESIGN: Randomized double-blind study. MATERIALS AND METHODS: A total of 90 patients were divided into three groups: G, P, C who received gabapentin 1200 mg, pregabalin 300 mg, and placebo, respectively 1.5 h before surgery. All patients received combined spinal-epidural block with 3 ml of 0.5% intrathecal bupivacaine. Assessment of pain was made with visual analog scale (VAS). Postoperative analgesia was provided with epidural top-ups with 2.5 ml of 0.5% bupivacaine and fentanyl 25 μg when VAS >3. Rescue analgesia in the form of injection diclofenac (75 mg) intramuscularly was given if VAS >3 even after epidural top-up. A total number of epidural top-ups, rescue analgesia, pain-free interval postspinal anesthesia, and sedation score were noted. STATISTICAL ANALYSIS: This was done using SPSS version 17. Mean and standard deviation were calculated using Chi-square test and analysis of variance. RESULTS: The total postoperative analgesic time was 7.23 h in Group G, 14.80 h in Group P, and 4.17 h in Group C. A total number of epidural top-ups were 2.43 in Group G, 0.77 in Group P, and 4.43 in Group C. CONCLUSION: Pregabalin 300 mg and gabapentin 1200 mg significantly reduce the need of postoperative rescue analgesia, epidural top-ups, and increase the duration of postspinal anesthesia without altering hemodynamics with sedation as a major side effect. |
format | Online Article Text |
id | pubmed-4864698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48646982016-05-20 Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique Khetarpal, Ranjana Kataria, Amar Parakash Bajaj, Samita Kaur, Harjinder Singh, Sudha Anesth Essays Res Original Article BACKGROUND: Pregabalin and gabapentin are the gamma-aminobutyric acid analogs used as a part of multimodal analgesic regimen. AIM: To compare the postoperative analgesic benefits of gabapentin or pregabalin as a premedication for lower limb orthopedic surgery under combined spinal-epidural techniques. SETTINGS AND DESIGN: Randomized double-blind study. MATERIALS AND METHODS: A total of 90 patients were divided into three groups: G, P, C who received gabapentin 1200 mg, pregabalin 300 mg, and placebo, respectively 1.5 h before surgery. All patients received combined spinal-epidural block with 3 ml of 0.5% intrathecal bupivacaine. Assessment of pain was made with visual analog scale (VAS). Postoperative analgesia was provided with epidural top-ups with 2.5 ml of 0.5% bupivacaine and fentanyl 25 μg when VAS >3. Rescue analgesia in the form of injection diclofenac (75 mg) intramuscularly was given if VAS >3 even after epidural top-up. A total number of epidural top-ups, rescue analgesia, pain-free interval postspinal anesthesia, and sedation score were noted. STATISTICAL ANALYSIS: This was done using SPSS version 17. Mean and standard deviation were calculated using Chi-square test and analysis of variance. RESULTS: The total postoperative analgesic time was 7.23 h in Group G, 14.80 h in Group P, and 4.17 h in Group C. A total number of epidural top-ups were 2.43 in Group G, 0.77 in Group P, and 4.43 in Group C. CONCLUSION: Pregabalin 300 mg and gabapentin 1200 mg significantly reduce the need of postoperative rescue analgesia, epidural top-ups, and increase the duration of postspinal anesthesia without altering hemodynamics with sedation as a major side effect. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4864698/ /pubmed/27212758 http://dx.doi.org/10.4103/0259-1162.172339 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Khetarpal, Ranjana Kataria, Amar Parakash Bajaj, Samita Kaur, Harjinder Singh, Sudha Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title | Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title_full | Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title_fullStr | Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title_full_unstemmed | Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title_short | Gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
title_sort | gabapentin vs pregabalin as a premedication in lower limb orthopaedics surgery under combined spinal epidural technique |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864698/ https://www.ncbi.nlm.nih.gov/pubmed/27212758 http://dx.doi.org/10.4103/0259-1162.172339 |
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