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Role of lupus retinopathy in systemic lupus erythematosus

BACKGROUND: Lupus retinopathy is one of the most common vision-threatening complications of systemic lupus erythematosus. The presence of lupus retinopathy is an accurate guide to the presence of active systemic disease activity. RESULTS: A prospective study was conducted looking at 91 established c...

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Autores principales: Kharel (Sitaula), Ranju, Shah, Dev Narayan, Singh, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864796/
https://www.ncbi.nlm.nih.gov/pubmed/27174124
http://dx.doi.org/10.1186/s12348-016-0081-4
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author Kharel (Sitaula), Ranju
Shah, Dev Narayan
Singh, Divya
author_facet Kharel (Sitaula), Ranju
Shah, Dev Narayan
Singh, Divya
author_sort Kharel (Sitaula), Ranju
collection PubMed
description BACKGROUND: Lupus retinopathy is one of the most common vision-threatening complications of systemic lupus erythematosus. The presence of lupus retinopathy is an accurate guide to the presence of active systemic disease activity. RESULTS: A prospective study was conducted looking at 91 established cases of systemic lupus erythematosus to evaluate lupus retinopathy. The patients were divided into two groups according to the presence or absence of lupus retinopathy, and a comparison of clinical and laboratory findings between two groups was done. Among 91 SLE patients, 5 were male and 86 were female; of which, 85 (93.4 %) were outpatients and 6 (6.6 %) were inpatients. Lupus retinopathy was found in 13 eyes of 11 cases out of 91 cases (12.1 %). Among these 13 eyes with lupus retinopathy, 61.5 % had mild type of lupus retinopathy, 15.4 % had moderate type, and 23.1 % had severe lupus retinopathy. The mean age of the cases at ophthalmological examination with and without retinopathy was 30.4 and 31.9 years, respectively. The mean serum creatinine level was 190.4 μmol/l which was higher than in the patients without retinopathy (96.2 μmol/l). The mean ESR in patients with retinopathy was higher than without retinopathy (34.2 vs. 32). Similarly, the mean platelet count in SLE patients with retinopathy was 154,245/μl and in SLE patients without retinopathy was 135,828/μl. CONCLUSIONS: Retinal lesions in SLE patients are of critical importance, both visually and prognostically.
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spelling pubmed-48647962016-05-31 Role of lupus retinopathy in systemic lupus erythematosus Kharel (Sitaula), Ranju Shah, Dev Narayan Singh, Divya J Ophthalmic Inflamm Infect Original Research BACKGROUND: Lupus retinopathy is one of the most common vision-threatening complications of systemic lupus erythematosus. The presence of lupus retinopathy is an accurate guide to the presence of active systemic disease activity. RESULTS: A prospective study was conducted looking at 91 established cases of systemic lupus erythematosus to evaluate lupus retinopathy. The patients were divided into two groups according to the presence or absence of lupus retinopathy, and a comparison of clinical and laboratory findings between two groups was done. Among 91 SLE patients, 5 were male and 86 were female; of which, 85 (93.4 %) were outpatients and 6 (6.6 %) were inpatients. Lupus retinopathy was found in 13 eyes of 11 cases out of 91 cases (12.1 %). Among these 13 eyes with lupus retinopathy, 61.5 % had mild type of lupus retinopathy, 15.4 % had moderate type, and 23.1 % had severe lupus retinopathy. The mean age of the cases at ophthalmological examination with and without retinopathy was 30.4 and 31.9 years, respectively. The mean serum creatinine level was 190.4 μmol/l which was higher than in the patients without retinopathy (96.2 μmol/l). The mean ESR in patients with retinopathy was higher than without retinopathy (34.2 vs. 32). Similarly, the mean platelet count in SLE patients with retinopathy was 154,245/μl and in SLE patients without retinopathy was 135,828/μl. CONCLUSIONS: Retinal lesions in SLE patients are of critical importance, both visually and prognostically. Springer Berlin Heidelberg 2016-05-12 /pmc/articles/PMC4864796/ /pubmed/27174124 http://dx.doi.org/10.1186/s12348-016-0081-4 Text en © Kharel (Sitaula) et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Kharel (Sitaula), Ranju
Shah, Dev Narayan
Singh, Divya
Role of lupus retinopathy in systemic lupus erythematosus
title Role of lupus retinopathy in systemic lupus erythematosus
title_full Role of lupus retinopathy in systemic lupus erythematosus
title_fullStr Role of lupus retinopathy in systemic lupus erythematosus
title_full_unstemmed Role of lupus retinopathy in systemic lupus erythematosus
title_short Role of lupus retinopathy in systemic lupus erythematosus
title_sort role of lupus retinopathy in systemic lupus erythematosus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864796/
https://www.ncbi.nlm.nih.gov/pubmed/27174124
http://dx.doi.org/10.1186/s12348-016-0081-4
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