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Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis

INTRODUCTION: To describe the characteristics, diagnosis, and treatment of the first documented case of Vogt–Koyanagi–Harada (VKH) disease following BCG vaccination (Patient 1) and the first documented case of both VKH disease and tuberculosis (Patient 2). Two patients were diagnosed with VKH diseas...

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Detalles Bibliográficos
Autores principales: Dogan, Berna, Erol, Muhammet Kazim, Cengiz, Ayse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864801/
https://www.ncbi.nlm.nih.gov/pubmed/27247899
http://dx.doi.org/10.1186/s40064-016-2223-4
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author Dogan, Berna
Erol, Muhammet Kazim
Cengiz, Ayse
author_facet Dogan, Berna
Erol, Muhammet Kazim
Cengiz, Ayse
author_sort Dogan, Berna
collection PubMed
description INTRODUCTION: To describe the characteristics, diagnosis, and treatment of the first documented case of Vogt–Koyanagi–Harada (VKH) disease following BCG vaccination (Patient 1) and the first documented case of both VKH disease and tuberculosis (Patient 2). Two patients were diagnosed with VKH disease and monitored using fundus photography, fundus autofluorescence, fluorescein angiography (FA), spectral-domain optical coherence tomography, and enhanced depth imaging optical coherence tomography (EDI-OCT). CASE DESCRIPTION: A 39-year-old patient (Patient 1) had bilateral granulomatous anterior uveitis and serous retinal detachment. FA showed multiple punctuate hyperfluorescent lesions and multilobular pools of dye. EDI-OCT revealed serous retinal detachment, subretinal septa, and cystoid spaces. A 40-year-old woman (Patient 2) presented with a 3-week history of decreased vision, headache and tinnitus. Fundus examination showed bilateral disc swelling with serous retinal detachment and retinal folds. She had been diagnosed with tuberculosis. EDI-OCT showed fluctuation of the internal limiting membrane (ILM), retinal folds, retinal pigment epithelial (RPE)-Bruch membrane undulation, choroidal folds, serous retinal detachment. Both of the patients received high dosage of steroid treatment during the diagnosis. A fast recovery in VKH symptoms was observed following the treatment. DISCUSSION AND EVALUATION: Immunological mechanisms and dysregulation of the immune system may play a significant role in the association between VKH disease and BCG. CONCLUSIONS: EDI-OCT imaging demonstrated structural changes in the photoreceptor layer, RPE-Bruch membrane, choroid, outer retina, ILM in acute VKH.
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spelling pubmed-48648012016-05-31 Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis Dogan, Berna Erol, Muhammet Kazim Cengiz, Ayse Springerplus Case Study INTRODUCTION: To describe the characteristics, diagnosis, and treatment of the first documented case of Vogt–Koyanagi–Harada (VKH) disease following BCG vaccination (Patient 1) and the first documented case of both VKH disease and tuberculosis (Patient 2). Two patients were diagnosed with VKH disease and monitored using fundus photography, fundus autofluorescence, fluorescein angiography (FA), spectral-domain optical coherence tomography, and enhanced depth imaging optical coherence tomography (EDI-OCT). CASE DESCRIPTION: A 39-year-old patient (Patient 1) had bilateral granulomatous anterior uveitis and serous retinal detachment. FA showed multiple punctuate hyperfluorescent lesions and multilobular pools of dye. EDI-OCT revealed serous retinal detachment, subretinal septa, and cystoid spaces. A 40-year-old woman (Patient 2) presented with a 3-week history of decreased vision, headache and tinnitus. Fundus examination showed bilateral disc swelling with serous retinal detachment and retinal folds. She had been diagnosed with tuberculosis. EDI-OCT showed fluctuation of the internal limiting membrane (ILM), retinal folds, retinal pigment epithelial (RPE)-Bruch membrane undulation, choroidal folds, serous retinal detachment. Both of the patients received high dosage of steroid treatment during the diagnosis. A fast recovery in VKH symptoms was observed following the treatment. DISCUSSION AND EVALUATION: Immunological mechanisms and dysregulation of the immune system may play a significant role in the association between VKH disease and BCG. CONCLUSIONS: EDI-OCT imaging demonstrated structural changes in the photoreceptor layer, RPE-Bruch membrane, choroid, outer retina, ILM in acute VKH. Springer International Publishing 2016-05-12 /pmc/articles/PMC4864801/ /pubmed/27247899 http://dx.doi.org/10.1186/s40064-016-2223-4 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Study
Dogan, Berna
Erol, Muhammet Kazim
Cengiz, Ayse
Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title_full Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title_fullStr Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title_full_unstemmed Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title_short Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis
title_sort vogt–koyanagi–harada disease following bcg vaccination and tuberculosis
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864801/
https://www.ncbi.nlm.nih.gov/pubmed/27247899
http://dx.doi.org/10.1186/s40064-016-2223-4
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