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The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk
Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants c...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864818/ https://www.ncbi.nlm.nih.gov/pubmed/26783083 http://dx.doi.org/10.1002/cam4.641 |
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| author | Becker, Jessica May, Andrea Gerges, Christian Anders, Mario Schmidt, Claudia Veits, Lothar Noder, Tania Mayershofer, Rupert Kreuser, Nicole Manner, Hendrik Venerito, Marino Hofer, Jan‐Hinnerk Lyros, Orestis Ahlbrand, Constantin J. Arras, Michael Hofer, Sebastian Heinrichs, Sophie K. M. Weise, Katharina Hess, Timo Böhmer, Anne C. Kosiol, Nils Kiesslich, Ralf Izbicki, Jakob R. Hölscher, Arnulf H. Bollschweiler, Elfriede Malfertheiner, Peter Lang, Hauke Moehler, Markus Lorenz, Dietmar Ott, Katja Schmidt, Thomas Nöthen, Markus M. Hackelsberger, Andreas Schumacher, Brigitte Pech, Oliver Vashist, Yogesh Vieth, Michael Weismüller, Josef Knapp, Michael Neuhaus, Horst Rösch, Thomas Ell, Christian Gockel, Ines Schumacher, Johannes |
| author_facet | Becker, Jessica May, Andrea Gerges, Christian Anders, Mario Schmidt, Claudia Veits, Lothar Noder, Tania Mayershofer, Rupert Kreuser, Nicole Manner, Hendrik Venerito, Marino Hofer, Jan‐Hinnerk Lyros, Orestis Ahlbrand, Constantin J. Arras, Michael Hofer, Sebastian Heinrichs, Sophie K. M. Weise, Katharina Hess, Timo Böhmer, Anne C. Kosiol, Nils Kiesslich, Ralf Izbicki, Jakob R. Hölscher, Arnulf H. Bollschweiler, Elfriede Malfertheiner, Peter Lang, Hauke Moehler, Markus Lorenz, Dietmar Ott, Katja Schmidt, Thomas Nöthen, Markus M. Hackelsberger, Andreas Schumacher, Brigitte Pech, Oliver Vashist, Yogesh Vieth, Michael Weismüller, Josef Knapp, Michael Neuhaus, Horst Rösch, Thomas Ell, Christian Gockel, Ines Schumacher, Johannes |
| author_sort | Becker, Jessica |
| collection | PubMed |
| description | Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence. |
| format | Online Article Text |
| id | pubmed-4864818 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48648182016-05-27 The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk Becker, Jessica May, Andrea Gerges, Christian Anders, Mario Schmidt, Claudia Veits, Lothar Noder, Tania Mayershofer, Rupert Kreuser, Nicole Manner, Hendrik Venerito, Marino Hofer, Jan‐Hinnerk Lyros, Orestis Ahlbrand, Constantin J. Arras, Michael Hofer, Sebastian Heinrichs, Sophie K. M. Weise, Katharina Hess, Timo Böhmer, Anne C. Kosiol, Nils Kiesslich, Ralf Izbicki, Jakob R. Hölscher, Arnulf H. Bollschweiler, Elfriede Malfertheiner, Peter Lang, Hauke Moehler, Markus Lorenz, Dietmar Ott, Katja Schmidt, Thomas Nöthen, Markus M. Hackelsberger, Andreas Schumacher, Brigitte Pech, Oliver Vashist, Yogesh Vieth, Michael Weismüller, Josef Knapp, Michael Neuhaus, Horst Rösch, Thomas Ell, Christian Gockel, Ines Schumacher, Johannes Cancer Med Cancer Biology Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence. John Wiley and Sons Inc. 2016-01-18 /pmc/articles/PMC4864818/ /pubmed/26783083 http://dx.doi.org/10.1002/cam4.641 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Cancer Biology Becker, Jessica May, Andrea Gerges, Christian Anders, Mario Schmidt, Claudia Veits, Lothar Noder, Tania Mayershofer, Rupert Kreuser, Nicole Manner, Hendrik Venerito, Marino Hofer, Jan‐Hinnerk Lyros, Orestis Ahlbrand, Constantin J. Arras, Michael Hofer, Sebastian Heinrichs, Sophie K. M. Weise, Katharina Hess, Timo Böhmer, Anne C. Kosiol, Nils Kiesslich, Ralf Izbicki, Jakob R. Hölscher, Arnulf H. Bollschweiler, Elfriede Malfertheiner, Peter Lang, Hauke Moehler, Markus Lorenz, Dietmar Ott, Katja Schmidt, Thomas Nöthen, Markus M. Hackelsberger, Andreas Schumacher, Brigitte Pech, Oliver Vashist, Yogesh Vieth, Michael Weismüller, Josef Knapp, Michael Neuhaus, Horst Rösch, Thomas Ell, Christian Gockel, Ines Schumacher, Johannes The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title | The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title_full | The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title_fullStr | The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title_full_unstemmed | The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title_short | The Barrett‐associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk |
| title_sort | barrett‐associated variants at gdf7 and tbx5 also increase esophageal adenocarcinoma risk |
| topic | Cancer Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864818/ https://www.ncbi.nlm.nih.gov/pubmed/26783083 http://dx.doi.org/10.1002/cam4.641 |
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