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Risk Factors for Development of Chronic Kidney Disease in Cats

BACKGROUND: Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. HYPOTHESIS/OBJECTIVES: Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. ANIMALS: One hundred and forty...

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Autores principales: Finch, N.C., Syme, H.M., Elliott, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864943/
https://www.ncbi.nlm.nih.gov/pubmed/26948860
http://dx.doi.org/10.1111/jvim.13917
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author Finch, N.C.
Syme, H.M.
Elliott, J.
author_facet Finch, N.C.
Syme, H.M.
Elliott, J.
author_sort Finch, N.C.
collection PubMed
description BACKGROUND: Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. HYPOTHESIS/OBJECTIVES: Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. ANIMALS: One hundred and forty‐eight client‐owned geriatric (>9 years) cats. METHODS: Cats were recruited into the study and followed longitudinally for a variable time. Owners were asked to complete a questionnaire regarding their pet at enrollment. Additional data regarding dental disease were obtained when available by development of a dental categorization system. Variables were explored in univariable and multivariable Cox regression models. RESULTS: In the final multivariable Cox regression model, annual/frequent vaccination (P value, .003; hazard ratio, 5.68; 95% confidence interval, 1.83–17.64), moderate dental disease (P value, .008; hazard ratio, 13.83; 95% confidence interval, 2.01–94.99), and severe dental disease (P value, .001; hazard ratio, 35.35; 95% confidence interval, 4.31–289.73) predicted development of azotemic CKD. CONCLUSION: Our study suggests independent associations between both vaccination frequency and severity of dental disease and development of CKD. Further studies to explore the pathophysiological mechanism of renal injury for these risk factors are warranted.
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spelling pubmed-48649432016-06-22 Risk Factors for Development of Chronic Kidney Disease in Cats Finch, N.C. Syme, H.M. Elliott, J. J Vet Intern Med SMALL ANIMAL BACKGROUND: Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. HYPOTHESIS/OBJECTIVES: Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. ANIMALS: One hundred and forty‐eight client‐owned geriatric (>9 years) cats. METHODS: Cats were recruited into the study and followed longitudinally for a variable time. Owners were asked to complete a questionnaire regarding their pet at enrollment. Additional data regarding dental disease were obtained when available by development of a dental categorization system. Variables were explored in univariable and multivariable Cox regression models. RESULTS: In the final multivariable Cox regression model, annual/frequent vaccination (P value, .003; hazard ratio, 5.68; 95% confidence interval, 1.83–17.64), moderate dental disease (P value, .008; hazard ratio, 13.83; 95% confidence interval, 2.01–94.99), and severe dental disease (P value, .001; hazard ratio, 35.35; 95% confidence interval, 4.31–289.73) predicted development of azotemic CKD. CONCLUSION: Our study suggests independent associations between both vaccination frequency and severity of dental disease and development of CKD. Further studies to explore the pathophysiological mechanism of renal injury for these risk factors are warranted. John Wiley and Sons Inc. 2016-03-06 2016 /pmc/articles/PMC4864943/ /pubmed/26948860 http://dx.doi.org/10.1111/jvim.13917 Text en Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Finch, N.C.
Syme, H.M.
Elliott, J.
Risk Factors for Development of Chronic Kidney Disease in Cats
title Risk Factors for Development of Chronic Kidney Disease in Cats
title_full Risk Factors for Development of Chronic Kidney Disease in Cats
title_fullStr Risk Factors for Development of Chronic Kidney Disease in Cats
title_full_unstemmed Risk Factors for Development of Chronic Kidney Disease in Cats
title_short Risk Factors for Development of Chronic Kidney Disease in Cats
title_sort risk factors for development of chronic kidney disease in cats
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864943/
https://www.ncbi.nlm.nih.gov/pubmed/26948860
http://dx.doi.org/10.1111/jvim.13917
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