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The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial
BACKGROUND: To evaluate the feasibility of executing a randomized controlled trial of progressive resistance training (PRT) in women with polycystic ovary syndrome (PCOS). METHODS: Women with PCOS were randomized to an experimental (PRT) group or a no-exercise (usual care) control group. The PRT gro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865007/ https://www.ncbi.nlm.nih.gov/pubmed/27175282 http://dx.doi.org/10.1186/s13102-016-0039-8 |
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author | Vizza, Lisa Smith, Caroline A. Swaraj, Soji Agho, Kingsley Cheema, Birinder S. |
author_facet | Vizza, Lisa Smith, Caroline A. Swaraj, Soji Agho, Kingsley Cheema, Birinder S. |
author_sort | Vizza, Lisa |
collection | PubMed |
description | BACKGROUND: To evaluate the feasibility of executing a randomized controlled trial of progressive resistance training (PRT) in women with polycystic ovary syndrome (PCOS). METHODS: Women with PCOS were randomized to an experimental (PRT) group or a no-exercise (usual care) control group. The PRT group was prescribed two supervised and two unsupervised (home-based) training sessions per week for 12 weeks. Feasibility outcomes included recruitment and attrition, adherence, adverse events, and completion of assessments. Secondary outcomes, collected pre and post intervention, included a range of pertinent physiological, functional and psychological measures. RESULTS: Fifteen participants were randomised into the PRT group (n = 8) or control group (n = 7); five women (n = 2 in PRT group and n = 3 in control group) withdrew from the study. The most successful recruitment sources were Facebook (40 %) and online advertisement (27 %), while least successful methods were referrals by clinicians, colleagues and flyers. In the PRT group, attendance to supervised sessions was higher (95 %; standard deviation ±6 %) compared to unsupervised sessions (51 %; standard deviation ±28 %). No adverse events were attributed to PRT. Change in menstrual cycle status was not significantly different between groups over time (p = 0.503). However, the PRT group significantly increased body weight (p = 0.01), BMI (p = 0.04), lean mass (p = 0.01), fat-free mass (p = 0.005) and lower body strength (p = 0.03), while reducing waist circumference (p = 0.03) and HbA(1c) (p = 0.033) versus the control group. The PRT group also significantly improved across several domains of disease-specific and general health-related quality of life, depression, anxiety and exercise self-efficacy. CONCLUSION: A randomized controlled trial of PRT in PCOS would be feasible, and this mode of exercise may elicit a therapeutic effect on clinically important outcomes in this cohort. The success of a large-scale trial required to confirm these findings would be contingent on addressing the feasibility hurdles identified in this study with respect to recruitment, attrition, compliance, and collection of standardized clinical data. TRIAL REGISTRATION: Australia New Zealand Clinical Trials Registry; ACTRN12614000517673 Registered 15 May 2014. |
format | Online Article Text |
id | pubmed-4865007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48650072016-05-13 The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial Vizza, Lisa Smith, Caroline A. Swaraj, Soji Agho, Kingsley Cheema, Birinder S. BMC Sports Sci Med Rehabil Research Article BACKGROUND: To evaluate the feasibility of executing a randomized controlled trial of progressive resistance training (PRT) in women with polycystic ovary syndrome (PCOS). METHODS: Women with PCOS were randomized to an experimental (PRT) group or a no-exercise (usual care) control group. The PRT group was prescribed two supervised and two unsupervised (home-based) training sessions per week for 12 weeks. Feasibility outcomes included recruitment and attrition, adherence, adverse events, and completion of assessments. Secondary outcomes, collected pre and post intervention, included a range of pertinent physiological, functional and psychological measures. RESULTS: Fifteen participants were randomised into the PRT group (n = 8) or control group (n = 7); five women (n = 2 in PRT group and n = 3 in control group) withdrew from the study. The most successful recruitment sources were Facebook (40 %) and online advertisement (27 %), while least successful methods were referrals by clinicians, colleagues and flyers. In the PRT group, attendance to supervised sessions was higher (95 %; standard deviation ±6 %) compared to unsupervised sessions (51 %; standard deviation ±28 %). No adverse events were attributed to PRT. Change in menstrual cycle status was not significantly different between groups over time (p = 0.503). However, the PRT group significantly increased body weight (p = 0.01), BMI (p = 0.04), lean mass (p = 0.01), fat-free mass (p = 0.005) and lower body strength (p = 0.03), while reducing waist circumference (p = 0.03) and HbA(1c) (p = 0.033) versus the control group. The PRT group also significantly improved across several domains of disease-specific and general health-related quality of life, depression, anxiety and exercise self-efficacy. CONCLUSION: A randomized controlled trial of PRT in PCOS would be feasible, and this mode of exercise may elicit a therapeutic effect on clinically important outcomes in this cohort. The success of a large-scale trial required to confirm these findings would be contingent on addressing the feasibility hurdles identified in this study with respect to recruitment, attrition, compliance, and collection of standardized clinical data. TRIAL REGISTRATION: Australia New Zealand Clinical Trials Registry; ACTRN12614000517673 Registered 15 May 2014. BioMed Central 2016-05-11 /pmc/articles/PMC4865007/ /pubmed/27175282 http://dx.doi.org/10.1186/s13102-016-0039-8 Text en © Vizza et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Vizza, Lisa Smith, Caroline A. Swaraj, Soji Agho, Kingsley Cheema, Birinder S. The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title | The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title_full | The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title_fullStr | The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title_full_unstemmed | The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title_short | The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
title_sort | feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865007/ https://www.ncbi.nlm.nih.gov/pubmed/27175282 http://dx.doi.org/10.1186/s13102-016-0039-8 |
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