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Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice

BACKGROUND: Potassium bromate (KBrO(3)) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO(3) administration on the brain functions and behaviour of albino mice. METHODS: Animals were divided into three groups: control,...

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Autores principales: Ajarem, Jamaan, Altoom, Naif G., Allam, Ahmed A., Maodaa, Saleh N., Abdel- Maksoud, Mostafa A., Chow, Billy KC.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865012/
https://www.ncbi.nlm.nih.gov/pubmed/27169539
http://dx.doi.org/10.1186/s12993-016-0098-8
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author Ajarem, Jamaan
Altoom, Naif G.
Allam, Ahmed A.
Maodaa, Saleh N.
Abdel- Maksoud, Mostafa A.
Chow, Billy KC.
author_facet Ajarem, Jamaan
Altoom, Naif G.
Allam, Ahmed A.
Maodaa, Saleh N.
Abdel- Maksoud, Mostafa A.
Chow, Billy KC.
author_sort Ajarem, Jamaan
collection PubMed
description BACKGROUND: Potassium bromate (KBrO(3)) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO(3) administration on the brain functions and behaviour of albino mice. METHODS: Animals were divided into three groups: control, low dose KBrO(3) (100 mg/kg/day) and high dose KBrO(3) (200 mg/kg/day) groups. RESULTS: Administration of KBrO(3) led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO(3) groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO(3) receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO(3)-treated animals. CONCLUSIONS: These results show that KBrO(3) has serious damaging effects on the central nervous system and therefore, its use should be avoided.
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spelling pubmed-48650122016-05-13 Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice Ajarem, Jamaan Altoom, Naif G. Allam, Ahmed A. Maodaa, Saleh N. Abdel- Maksoud, Mostafa A. Chow, Billy KC. Behav Brain Funct Research BACKGROUND: Potassium bromate (KBrO(3)) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO(3) administration on the brain functions and behaviour of albino mice. METHODS: Animals were divided into three groups: control, low dose KBrO(3) (100 mg/kg/day) and high dose KBrO(3) (200 mg/kg/day) groups. RESULTS: Administration of KBrO(3) led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO(3) groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO(3) receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO(3)-treated animals. CONCLUSIONS: These results show that KBrO(3) has serious damaging effects on the central nervous system and therefore, its use should be avoided. BioMed Central 2016-05-12 /pmc/articles/PMC4865012/ /pubmed/27169539 http://dx.doi.org/10.1186/s12993-016-0098-8 Text en © Ajarem et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ajarem, Jamaan
Altoom, Naif G.
Allam, Ahmed A.
Maodaa, Saleh N.
Abdel- Maksoud, Mostafa A.
Chow, Billy KC.
Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title_full Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title_fullStr Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title_full_unstemmed Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title_short Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
title_sort oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865012/
https://www.ncbi.nlm.nih.gov/pubmed/27169539
http://dx.doi.org/10.1186/s12993-016-0098-8
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