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Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8(+) T Cells
Interferon Regulatory Factor-8 (IRF8) is constitutively expressed in monocytes and B cell lineages and plays important roles in immunity to pathogens and cancer. Although IRF8 expression is induced in activated T cells, the functional relevance of IRF8 in T cell-mediated immunity is not well underst...
Autores principales: | Sun, Lin, St. Leger, Anthony J., Yu, Cheng-Rong, He, Chang, Mahdi, Rashid M., Chan, Chi-Chao, Wang, Hongsheng, Morse, Herbert C., Egwuagu, Charles E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865128/ https://www.ncbi.nlm.nih.gov/pubmed/27171004 http://dx.doi.org/10.1371/journal.pone.0155420 |
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