Screening for novel hexanucleotide repeat expansions at ALS- and FTD-associated loci

OBJECTIVE: To determine whether GGGGCC (G(4)C(2)) repeat expansions at loci other than C9orf72 serve as common causes of amyotrophic lateral sclerosis (ALS). METHODS: We assessed G(4)C(2) repeat number in 28 genes near known ALS and frontotemporal dementia (FTD) loci by repeat-primed PCR coupled wit...

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Detalles Bibliográficos
Autores principales: He, Fang, Jones, Julie M., Figueroa-Romero, Claudia, Zhang, Dapeng, Feldman, Eva L., Goutman, Stephen A., Meisler, Miriam H., Callaghan, Brian C., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865132/
https://www.ncbi.nlm.nih.gov/pubmed/27274540
http://dx.doi.org/10.1212/NXG.0000000000000071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865132/
https://www.ncbi.nlm.nih.gov/pubmed/27274540
http://dx.doi.org/10.1212/NXG.0000000000000071

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