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Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia
RATIONALE: Congenital diaphragmatic hernia (CDH) is associated with a high incidence of respiratory problems, even after initial hospital discharge. These problems are likely to lead to re-hospitalization during infancy, although actual frequency of readmissions is unknown. OBJECTIVE: We aimed to de...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865179/ https://www.ncbi.nlm.nih.gov/pubmed/27171167 http://dx.doi.org/10.1371/journal.pone.0155556 |
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author | Benoist, Gregoire Mokhtari, Mostafa Deschildre, Antoine Khen-Dunlop, Naziha Storme, Laurent Benachi, Alexandra Delacourt, Christophe |
author_facet | Benoist, Gregoire Mokhtari, Mostafa Deschildre, Antoine Khen-Dunlop, Naziha Storme, Laurent Benachi, Alexandra Delacourt, Christophe |
author_sort | Benoist, Gregoire |
collection | PubMed |
description | RATIONALE: Congenital diaphragmatic hernia (CDH) is associated with a high incidence of respiratory problems, even after initial hospital discharge. These problems are likely to lead to re-hospitalization during infancy, although actual frequency of readmissions is unknown. OBJECTIVE: We aimed to determine the rate of hospitalization for wheezing in infants with CDH between the time of initial discharge and 24 months of age, and to identify factors associated with readmission. METHODS: Data about infants with CDH born in three French reference tertiary centers between January 2009 and March 2013 who were alive at hospital discharge, were extracted from a prospective national database. RESULTS: Ninety-two children were identified, and 86 were included in the analysis. In total, 116 wheezing episodes requiring a doctor’s visit occurred in 50 infants (58%) before 24 months of age. Twenty-two children (26%) were readmitted at least once for wheezing exacerbations. RSV was present in 6 of 15 (40%) of children with available nasal samples at first readmission, and 1 of 5 (20%) at second readmission. Thoracic herniation of the liver, low gestational age, longer initial hospitalization, need for oxygen therapy at home, and eczema were all significantly associated with readmission for wheezing exacerbations. Fifty-three infants (62%) received palivizumab prophylaxis, but there was no association with the overall rate of readmission for wheezing exacerbations or RSV-related hospitalization. CONCLUSIONS: The rate of readmission for wheezing among infants with CDH is high, and significantly influenced by several prenatal and neonatal factors. Palivizumab prophylaxis was not associated with the rate of readmission. |
format | Online Article Text |
id | pubmed-4865179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48651792016-05-26 Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia Benoist, Gregoire Mokhtari, Mostafa Deschildre, Antoine Khen-Dunlop, Naziha Storme, Laurent Benachi, Alexandra Delacourt, Christophe PLoS One Research Article RATIONALE: Congenital diaphragmatic hernia (CDH) is associated with a high incidence of respiratory problems, even after initial hospital discharge. These problems are likely to lead to re-hospitalization during infancy, although actual frequency of readmissions is unknown. OBJECTIVE: We aimed to determine the rate of hospitalization for wheezing in infants with CDH between the time of initial discharge and 24 months of age, and to identify factors associated with readmission. METHODS: Data about infants with CDH born in three French reference tertiary centers between January 2009 and March 2013 who were alive at hospital discharge, were extracted from a prospective national database. RESULTS: Ninety-two children were identified, and 86 were included in the analysis. In total, 116 wheezing episodes requiring a doctor’s visit occurred in 50 infants (58%) before 24 months of age. Twenty-two children (26%) were readmitted at least once for wheezing exacerbations. RSV was present in 6 of 15 (40%) of children with available nasal samples at first readmission, and 1 of 5 (20%) at second readmission. Thoracic herniation of the liver, low gestational age, longer initial hospitalization, need for oxygen therapy at home, and eczema were all significantly associated with readmission for wheezing exacerbations. Fifty-three infants (62%) received palivizumab prophylaxis, but there was no association with the overall rate of readmission for wheezing exacerbations or RSV-related hospitalization. CONCLUSIONS: The rate of readmission for wheezing among infants with CDH is high, and significantly influenced by several prenatal and neonatal factors. Palivizumab prophylaxis was not associated with the rate of readmission. Public Library of Science 2016-05-12 /pmc/articles/PMC4865179/ /pubmed/27171167 http://dx.doi.org/10.1371/journal.pone.0155556 Text en © 2016 Benoist et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Benoist, Gregoire Mokhtari, Mostafa Deschildre, Antoine Khen-Dunlop, Naziha Storme, Laurent Benachi, Alexandra Delacourt, Christophe Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title | Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title_full | Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title_fullStr | Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title_full_unstemmed | Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title_short | Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia |
title_sort | risk of readmission for wheezing during infancy in children with congenital diaphragmatic hernia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865179/ https://www.ncbi.nlm.nih.gov/pubmed/27171167 http://dx.doi.org/10.1371/journal.pone.0155556 |
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